Biopsy Wound
Conditions
Keywords
Biopsy, Wound Healing, Bandages, Hydrocolloid, Dermatology, Anti-Bacterial Agents
Brief summary
The main objective of this study is to determine the efficacy of using hydrocolloid dressing on wound healing of post-punch biopsy wounds vs topical antibiotic. Specifically, it aims to measure the following parameters: the presence or absence of infection, the clinical estimate of reepithelialization, the clinical estimate of wound closure, scar formation, pigmentation of scar, and the cosmetic appearance of the wound. The study is a double-blind randomized controlled trial which will be conducted at the Dermatology outpatient department and the private clinics of dermatology consultants of the University of Santo Tomas Hospital. Patients who will be included are those who are 18 to 64 years of age with clean cutaneous lesions. Excluded from this study are those who have infected wounds, those who have conditions with poor tendency to heal including diabetes mellitus, peripheral vascular disease, history of keloid formation, those currently receiving anticoagulation therapy or systemic corticosteroids, and those known to have hypersensitivity to topical antibiotics. The primary outcome measure is the proportion of patients who achieved better overall healing when treated with hydrocolloid dressing.
Interventions
DRUGMupirocin (drug)
Wounds were dressed with gauze impregnated with mupirocin ointment covered by a transparent dressing (Tegaderm)
Wounds were dressed with a 1-inch size Duoderm Control Gel Formula hydrocolloid dressing
Sponsors
University of Santo Tomas Hospital, Philippines
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients 18 to 64 years old with clean cutaneous lesions who underwent skin punch biopsy using 3-mm disposable biopsy puncher.
Exclusion criteria
* Patients with infected wounds. * Patients with conditions with poor tendency to heal including diabetes mellitus, peripheral vascular disease, history of keloid formation, patients currently receiving anticoagulation therapy or systemic corticosteroids. * Patients known to have hypersensitivity to topical antibiotics.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Absence or Presence of Infection | 5 days after punch biopsy. | Absent - millimeters of surrounding erythema or equivocal findings Present - as inferred by indurated erythema or purulent discharge |
| Clinical Estimate of Reepithelialization | 5 days after punch biopsy | Rated on a scale of: * 0% to 25% * 26% to 50% * 51% to 75% * 76% to 100% |
| Clinical Estimate of Wound Closure | 5 days after punch biopsy | Rated on a scale of: * 0% to 25% * 26% to 50% * 51% to 75% * 76% to 100% |
| Scar Formation | 5 days after punch biopsy | Select one of the following for the assessment: * Unhealed * Depressed or Atrophied * Normal fine-line scar * Hypertrophied scar or Keloid |
| Scar Pigmentation | 5 days after punch biopsy | Select one of the following for the assessment: * Indeterminate or Unhealed * Normal * Hyperpigmented * Hypopigmented |
| Cosmetic Appearance | 5 days after punch biopsy | Select one of the following for the assessment: * Indeterminate or Unhealed * Poor * Fair * Good * Excellent |
Countries
Philippines
Outcome results
None listed