COPD
Conditions
Keywords
Oxygen, Exercise, Rehabilitation
Brief summary
Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.
Interventions
OTHERambiant air
Standard ambiant air will be breathed during endurance training. ambiant air
OTHEROxygen
SSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training
Sponsors
Eastern Switzerland University of Applied Sciences
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged ≥18 years * Stable clinical condition for \>3 weeks (e.g., no exacerbations) * Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT * Informed consent documented by signature
Exclusion criteria
* Severe daytime resting hypoxemia (SpO₂ \<88%) * Long-term oxygen therapy * Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities * Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle) * Women who are pregnant or breastfeeding * Enrolment in another clinical trial involving active treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1. Change in Rrs (Respiratory System Resistance) before and after rehabilitation cycle | baseline to 3 weeks | Rrs will be measured using the forced oscillation technique (FOT) in cmH₂O·s/L. Values will be assessed before and after the pulmonary rehabilitation cycle at moderate altitude |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Xrs (Respiratory System Reactance) compared before and after the pulmonary rehabilitation. | baseline to 3 weeks | Xrs will be measured using FOT in cmH₂O·s/L. Values will be compared before and after the pulmonary rehabilitation |
| Change in ∆Xrs (Difference in Reactance) before and after rehabilitation | baseline to 3 weeks | ∆Xrs will be calculated as the difference between inspiratory and expiratory Xrs values, measured in cmH₂O·s/L, before and after rehabilitation. |
| Change in Rrs, Xrs and ∆Xrs from low to moderate altitude | From baseline at low altitude to transfer to moderate altitude at 3 days | — |
Countries
Kyrgyzstan, Switzerland
Outcome results
None listed