Major Depression
Conditions
Keywords
Depression, Aerobic exercise, Oxidative stress, Growth factors
Brief summary
This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.
Interventions
Volunteers participating in the study who were included in the experimental group performed breathing exercises every day for three weeks. They were taught to focus their attention on the hand on their abdominal area while breathing slowly through their nose and to increase abdominal movement while reducing chest movement. They were warned that during inspiration, as air filled their lungs, the hand on their abdomen should rise upward and the hand on their chest should not move excessively. Participants continued the training until they performed the exercise correctly. The diaphragmatic breathing exercise was performed for 10 minutes in the supine position during the first week, in the semi-sitting and/or sitting position during the second week, and in the standing position during the final week.
The ratios determined as reference values for walking training in healthy adults (reference value for women = (2.11\*height) - (2.29\*body weight) - (5.78\*age) + 667 meters - reference value for men = (7.57\*height) - (1.76\*body weight) - (5.0 2\*age) - 309 meters) was performed at 80% intensity for at least 30 minutes on at least 3 days a week for 3 weeks. Aerobic exercise was considered for 3 weeks to facilitate adaptation to exercise and sustainability.
Sponsors
Study design
Eligibility
Inclusion criteria
* Individuals who volunteer to participate in the study, * Between the ages of 18 and 40, * Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria
Exclusion criteria
* Individuals with chronic conditions accompanying depression, * Those with walking difficulties * Those with respiratory system disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxidative stress biomarkers | From enrollment to the end of treatment at 3 weeks | It has been reported that the interaction between oxidative stress and the immune system is important, and that activated immune inflammatory pathways can trigger oxidative stress. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of oxidative stress (TAS, TOS, MDA, and F2-isoprostane) biomarkers, which play a role in the pathophysiology of depression. |
| Proinflmatuar sytokines | From enrollment to the end of treatment at 3 weeks | It is believed that increased production of key proinflammatory cytokines such as interleukin tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 (IL-1) and acute phase reactants plays an important role in the development of depression as a result of immune system involvement. In our study, an ELISA test will be conducted to investigate how exercise affects the levels of inflammation (TNF-α, IL-6, IL-1) which play a role in the pathophysiology of depression. |
Countries
Turkey (Türkiye)