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Study on Outcomes of Proximal Humerus Fractures

Review of Proximal Humerus Fracture Outcomes

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07060664
Enrollment
100
Registered
2025-07-11
Start date
2026-09-01
Completion date
2028-07-01
Last updated
2025-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proximal Humerus Fracture

Keywords

proximal humerus fracture, humerus, fracture, shoulder, ORIF, IMN, nail, open reduction internal fixation

Brief summary

Patients undergoing either operative or non-operative treatment of proximal humerus fractures will be studied with the goal of understanding which treatment modality provides optimal post-injury outcomes.

Interventions

treatment with open reduction and plates/screws

open reduction and intramedullary nail

PROCEDUREreverse total shoulder arthroplasty

reverse total shoulder arthroplasty

Sponsors

University of Massachusetts, Worcester
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* individuals 65 years of age or older with proximal humerus fractures

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frameDescription
Range of Motion (ROM)at 3 months, 6 months, 12 months, and 24 months from initiation of treatmentRange of Motion of the shoulder in terms of degrees of motion Assessment of forward flexion (0-180 degrees), abduction (0-90 degrees), external rotation (0-90 degrees)
SANEat 3 months, 6 months, 12 months, and 24 months following initiation of treatmentSane outcome typically refers to the Single Assessment Numeric Evaluation (SANE) score, a patient-reported outcome measure used in healthcare, particularly in orthopedics. It assesses a patient's perceived function of a joint or body region by asking them to rate it on a scale of 0 to 100, where 100 represents normal function
VASat 3 months, 6 months, 12 months, and 24 months following initiation of interventionVAS outcome refers to the results obtained from using a Visual Analog Scale (VAS). The VAS is a measurement tool, typically a 10 cm or 100 mm line, where individuals indicate the intensity of a subjective experience, such as pain, by marking a point on the line. The distance from one end of the line to the patient's mark is then measured, and this measurement represents the VAS score. A higher score indicates a greater intensity of the experience being measured.
ASESat 3 months, 6 months, 12 months, and 24 months following initiation of interventionThe American Shoulder and Elbow Surgeons scale (ASES) is a condition-specific scale that is intended to measure functional limitations and pain of the shoulder. A higher ASES score indicates better shoulder function and less pain, with a score of 100 representing the best possible outcome and a score of 0 representing the worst possible outcome.
EQ-5D-5Lat baseline and subsequently at 3 months, 6 months, 12 months, and 24 months following initiation of interventionThe EQ-5D-5L score represents a patient's self-reported health status, with values ranging from -0.59 to 1, where 1 indicates the best possible health. It's based on five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, each with five levels of severity. These responses are converted into a single index score using a scoring algorithm.
Brophy/Marxat baseline and subsequently at 12 months and 24 months after initiation of interventionThe Brophy-Marx Shoulder Activity Score is a valid and reliable shoulder-specific questionnaire that measures a patient's shoulder activity level over the previous year. The questionnaire generates a numeric score from 0 (least active) to 20 (most active).
PROMIS Socialat 3 months, 12 months, and 24 months following initiation of interventionPROMIS, or the Patient-Reported Outcomes Measurement Information System, uses T-scores to represent social health, with a mean of 50 and a standard deviation of 10 for the general US population. Higher T-scores generally indicate a greater amount of the measured concept, such as satisfaction with social roles and activities, while lower scores indicate less.
Radiographic Outcomeat 3 months, 6 months, 12 months, and 24 months following initiation of interventionevidence of bony healing, nonunion, or malunion of the fracture on imaging
Complication Rateat 3 months, 6 months, 12 months, and 24 months following initiation of interventionRate of complications following initiation of management

Countries

United States

Contacts

Primary ContactGregory Iovanel, MD
iovanel.gregory@gmail.com401-651-8188

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026