PCOS
Conditions
Brief summary
The study aimed to assess how a 6-month insulin sensitizer therapy impacts insulin resistance, glucose tolerance, and hormonal levels in women with PCOS. Researchers evaluated 156 PCOS patients, measuring their BMI, HOMA-IR (for insulin resistance), TyG index, TyG index-BMI, and total testosterone. Participants were divided into two groups, receiving either metformin or a myoinositol/d-chiro-inositol combination for six months, after which all parameters were re-evaluated to determine the percentage of change.
Interventions
metformin (MET) hydrochloride 500 mg three times daily as the standard insulin sensitizer.
DRUGMyoinositol
myoinositol/d-chiro-inositol combination (MYO/DCI) in 40:1 ratiotwice daily
Sponsors
Benha University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
23 Years to 47 Years
Healthy volunteers
No
Inclusion criteria
* Patients presenting manifestations suggestive of having PCOS; * Patients were free of
Exclusion criteria
.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Success Rate of Treatment Regimens in Restoring Menstrual Regularity and/or Achieving Pregnancy | 6~7 Months | The proportion of patients who regained a regular menstrual pattern and/or achieved pregnancy during the study, reflecting the effectiveness of the administered treatment regimens. |
Countries
Egypt
Outcome results
None listed