Dexmedetomidine as an Additive for (Ipack)Block in Knee Surgery

Analgesic Effect of Using Dexmedetomidine as an Additive for (Ipack)Block in Knee Surgeries in Adult Patient; A Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07058493

Enrollment

Registered

2025-07-10

Start date

2024-01-02

Completion date

2024-07-30

Last updated

2025-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Surgeries

Brief summary

Dexmedetomidine used as an Additive for Ipack Block in Knee Surgery

Detailed description

Many types of analgesia used but multimodal analgesia showed best results The interspace between the popliteal artery and capsule of the posterior knee (IPACK) block aims to blockade of sciatic nerve terminal branches for analgesia without motor affection . (IPACK) block is a motor power sparing procedure that involves injecting local anesthetic into the space between the popliteal artery and the posterior capsule of the knee in order to treat posterior knee pain

Interventions

DRUGDexmedetomidine

dexmedetomidine 100 μg as adjuvant to IPACK block with 20 ml of bupivacaine 0.25%.

DRUGBupivacaine

20 ml of bupivacaine 0.25%.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* 18-60 years * ASA I, II .patients undergoing knee surgeries.

Exclusion criteria

* patient Refusal * bleeding disorders * skin lesion * infection * known allergy * contradictions of spinal anesthesia

Design outcomes

Primary

Measure	Time frame	Description
Visual Analog Scale at rest score during first postoperative 48 hours	48 postoperative hours	Visual Analog Scale at rest during first postoperative 48 hours a line 10centimeters long from zero to10 where 10 is the worst pain ever

Secondary

Measure	Time frame	Description
Visual Analog Scale at rest and during movement at 30 minuts, 2, 8, 16, 24, 36, and 48 hours	48 postoperative hours	Visual Analog Scale at rest during 48 postoperative hour a line 10centimeters long from zero to10 where 10 is the worst pain ever
Duration of the block	48 hours	Duration of the block
Heart Rate	48 hours	Heart Rate
Mean Arterial Pressure	48 hours	Mean Arterial Pressure
Block performance time in minutes	preoperative	Block performance time in minutes
Incidence of adverse effects	2 hours inPACU	Incidence of adverse effects

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026