Microbiome and Colorectal Cancer Recurrence

The Role of Microbiome in Recurrence After Colorectal Cancer Surgery With Postoperative Organ/Space Surgical Site Infection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07057076

Enrollment

Registered

2025-07-09

Start date

2004-01-01

Completion date

2024-06-01

Last updated

2025-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer Recurrent

Keywords

Colorectal cancer, Anastomotic leak, Microbiome, Tumor recurrence

Brief summary

Anastomotic leak is associated with higher rates of tumor recurrence after colorectal cancer surgery. However, the mechanisms responsible remain unknown. The aim of this study is to identify associations between the peritoneal microbiome and recurrence in colorectal cancer patients with postoperative anastomotic leak. This is a single-center retrospective study of patients undergoing colorectal cancer surgery complicated with anastomotic leak between 2004 and 2012. Samples of peritoneal fluid were collected either through percutaneous drainage or reoperation, and microbiome was analyzed using whole genome shotgun. Oncological outcomes are registered. Associations between peritoneal microbiome and tumor recurrence are investigated.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Colorectal cancer patients operated on for cure and complicated with anastomotic leak.

Exclusion criteria

* Non-curative resection. * Urgent surgery.

Design outcomes

Primary

Measure	Time frame	Description
Recurrence	5 years	Colorectal cancer recurrence after surgery

Outcome results