Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive Periodontitis

The Effect of Adjunct Use of Diode Laser Therapy and Omega 3 Gel in Local Drug Delivery Approach on The Treatment of Localized Aggressive Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07056257

Enrollment

Registered

2025-07-09

Start date

2022-05-08

Completion date

2025-03-07

Last updated

2025-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diode Laser Therapy, Localized Aggressive Periodontitis, Omega 3

Brief summary

This study aims to evaluate and compare the effect of combination therapy between diode laser and omega3 gel in the local drug delivery approach as an adjunct to scaling and root planning on the management of localized aggressive periodontitis clinically and immunologically.

Detailed description

Periodontitis is a disease of the periodontium occurring in an otherwise healthy adolescent, which is characterized by a rapid loss of alveolar bone about more than one tooth of the permanent dentition. The laser approach is an efficient and atraumatic technique to enhance its use for periodontal treatment. Within the limits of scientific data, treatment with diode laser and SRP showed a higher effect than SRP or laser alone. Omega3 Polyunsaturated fatty acids (PUFA) have well recognized anti-inflammatory properties. They decrease inflammation through multiple pathways.

Interventions

PROCEDUREScaling-root planning (SRP)

Thirteen sites \[scaling-root planning (SRP)\] were used as a control group.

PROCEDUREScaling-root planning (SRP)+ laser therapy

Thirteen sites \[scaling-root planning (SRP)+ laser therapy with application of methyl cellulose gel at repeated times weekly for one month\].

PROCEDUREScaling-root planning (SRP)+ omega 3 gel

Thirteen sites \[scaling-root planning (SRP) + omega 3 gel repeated time weekly for one month\].

PROCEDUREScaling-root planning (SRP)+ laser therapy+ omega 3 gel

Thirteen sites \[combination therapy between scaling-root planning (SRP) + laser + omega 3 gel in repeated time weekly for one month\].

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

* Patients diagnosed with localized aggressive periodontitis. * Patients must be medically free. * Optimal compliance as evidenced by no missed treatment appointments and a positive attitude to maintain oral hygiene. * Patients who are willing to participate in this study can enroll and complete it.

Exclusion criteria

* Patients with generalized aggressive periodontitis. Patients are over 35 years old. * Pregnancy. * Patients had scaling and root planning or antibiotic therapy in the last 6 months. * Patients with hypersensitivity to fish oil.

Design outcomes

Primary

Measure	Time frame	Description
Pocket depth	6 months post-procedure	Probing pocket depth (PD) was recorded according to Ramfijord 1967.

Secondary

Measure	Time frame	Description
Plaque score	6 months post-procedure	Plaque score was recorded according to Silness and loe 1964.
Bleeding on probing	6 months post-procedure	Bleeding on probing (BOP) according to Ainamo and Bay 1975.
Clinical attachment level loss	6 months post-procedure	Clinical attachment level loss (CAL) according to according to Ramfijord 1967.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026