Hypertension
Conditions
Brief summary
My research explores the antihypertensive effects of Nigella sativa (black seed) oil in managing high blood pressure. Hypertension is a growing global health concern, often insufficiently controlled by standard medications. Nigella sativa, known for its bioactive compound thymoquinone, possesses antioxidant, anti-inflammatory, and vasodilatory properties, making it a potential natural remedy for blood pressure regulation.
Interventions
COMBINATION_PRODUCTNigella sativa (black seed)
Participants in Group 1 (intervention group) will receive Nigella sativa (black seed) oil at a dosage of 0.5 ml, administered orally twice daily-once before breakfast and once before bedtime-for a duration of 12 weeks. The oil, sourced from a standardized local supplier, is rich in thymoquinone, known for its antioxidant and vasodilatory properties. Blood pressure will be measured at baseline and biweekly intervals using a calibrated digital sphygmomanometer to monitor changes in systolic and diastolic values. Participants will also be monitored regularly for any adverse effects.
Sponsors
Superior University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 30 to 70 years * Diagnosed with mild to moderate hypertension (BP ≥140/90 mmHg) * Willing to participate and provide written informed consent * Not currently on any herbal or nutritional supplements
Exclusion criteria
* History of smoking or alcohol consumption * Pregnant, postmenopausal, or breastfeeding women * Use of dietary supplements or medications containing antioxidants, caffeine, estrogen, or steroids * Individuals engaging in regular vigorous physical exercise * Those adding extra salt to their meals * Known allergy to Nigella sativa or black seed oil
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Structured Patient History Questionnaire | 12 Months | A pre-designed, structured questionnaire will be used at baseline to collect demographic information, medical history, medication use, dietary habits, and lifestyle factors. This is a qualitative tool without a scoring system but is essential for eligibility confirmation and contextual analysis |
Countries
Pakistan
Outcome results
None listed