Actinic Prurigo
Conditions
Keywords
Actinic prurigo, subtype actinic prurigo, HLA typing, genetic
Brief summary
This research project investigates the clinical and genetic associations of Actinic Prurigo (AP) in the Thai population. As a rare chronic photodermatosis, AP has been observed to occur more frequently in individuals with certain genetic predispositions, particularly specific Human Leukocyte Antigen (HLA) types. Previous studies have suggested variations in clinical presentation and HLA allele distributions between Asian and Western populations. The primary aim is to explore the relationship between clinical manifestations of AP and genetic profiles, including HLA typing, among Thai individuals. Additionally, the study seeks to examine whether different HLA types are associated with varying responses to treatment. The study design is a cross-sectional comparative study, involving both AP patients and age-matched healthy controls. Given the rarity of the condition, patient recruitment will be conducted across four collaborating institutions: King Chulalongkorn Memorial Hospital Siriraj Hospital Institute of Dermatology
Interventions
DIAGNOSTIC_TESTTargeted long-read HLA sequencing
Genetic study
OTHERRNA extraction
Nanostring technology, Seattle
OTHERFull Skin examination
Skin and mucosa examination
Sponsors
Chulalongkorn University
Health Systems Research Institute,Thailand
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Thai ethnicity * Diagnosed with Actinic Prurigo (AP) according to the diagnostic criteria defined for this study * Mentally competent, able to communicate, and able to read Thai. * Participants receiving Thalidomide treatment must use two simultaneous methods of contraception, starting at least 4 weeks prior to initiating the medication and continuing throughout the treatment period and for at least 4 weeks after discontinuation.
Exclusion criteria
* History and physical examination findings suggestive of other photodermatoses such as Lupus erythematosus, Porphyria, or Polymorphous Light Eruption, among others. * Elevated Epstein-Barr Virus (EBV) viral load detected in blood testing (EBV viral load will be tested in all participants). * Low Minimal Erythema Dose (MED) to UVB radiation as the only abnormal finding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Targeted long-read HLA sequencing | through study completion, an average of 1 year | Correlation between the occurrence of Actinic Prurigo (AP), its clinical manifestations, and genetic factors-including HLA types-in individuals of Thai ancestry. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Short-read whole genome sequencing (WGS) | through study completion, an average of 1 year | Correlation between the occurrence of Actinic Prurigo (AP), its clinical manifestations, and genetic factors-including short-read whole genome sequencing (WGS)-in individuals of Thai ancestry. |
| Immunology study | through study completion, an average of 1 year | Correlation between the occurrence of Actinic Prurigo (AP), its clinical manifestations, and immunological factors in individuals of Thai ancestry, measured by RNA extraction and gene expression analysis. |
Countries
Thailand
Contacts
CONTACTEinapak Boontaveeyuwat, MD
CONTACTKittima Leklad
Outcome results
None listed