Comparison of the Impact of Different Suspension Mediums on ABO Antibody Titres.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07054372

Enrollment

200

Registered

2025-07-08

Start date

2024-08-01

Completion date

2024-11-30

Last updated

2025-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Blood Donor

Brief summary

Accurate estimation of ABO antibody titres is vital in Transfusion Medicine due to their involvement in hemolytic transfusion reactions, hemolytic disease of the fetus and newborn, and solid-organ transplant rejection. Although the conventional tube technique (CTT) remains the gold standard, its standardization is challenging, partly influenced by the choice of diluents. This study aimed to compare commonly used diluents in ABO antibody titration via CTT and analyze the resulting titre variations.

Interventions

DIAGNOSTIC_TESTTitres on conventional test tube method with different diluent

Titres on conventional test tube method with different diluent

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

\- Healthy Blood Donor.

Exclusion criteria

\- Samples from female donors, those with irregular antibodies and reactive to transfusion-transmissible infections on routine testing, were excluded.

Design outcomes

Primary

Measure	Time frame
Comparison of the ABO Antibody Titres.	Day 0

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026