Delfi Cuff, Fitcuff, Placebo - Control
Conditions
Brief summary
This study will investigate the use of different blood flow restriction cuffs during leg press exercise on arterial stiffness, muscle morphology, performance, and participant perception.
Detailed description
This study aims to investigate the use of Delfi vs. Fitcuffs blood flow restriction (BFR) cuff exercise on indices of arterial stiffness, muscle morphology, performance, and participant perception. Thirty adults aged 18-40 years old will undergo three treatment sessions (control (no BFR), Delfi BFR, and Fitcuffs BFR) in a randomized order separated by one week. A familiarization session will also occur one week before starting the treatment period. Each subject will undergo a series of tests including anthropometry, applanation tonometry, ultrasonography of the vastus lateralis, blood pressure acquisition, body composition, and maximal strength assessments (1RM). The exercise trial will consist of sets of leg press exercises performed to failure with a 2-second concentric and 2-second eccentric cadence at 20% of their 1RM using 60% of the supine limb occlusion pressure (LOP) with 1-minute rest intervals. Assessments will be performed immediately before and after the exercise bout during each treatment session. Two-way ANOVAs will be used to examine the main effects of treatment and treatment-order interaction on pulse wave velocity, muscle cross-sectional area, and perceptual response.
Interventions
DEVICEDelfi blood flow restriction cuff
Leg press exercise with Delfi blood flow restriction cuff
DEVICEFitcuffs
Leg press exercise with Fitcuff blood flow restriction cuff
OTHERControl
Leg press exercise with no blood flow restriction cuff
Sponsors
Salisbury University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Physically active (\> 1,000 MET/min/wk) for at least six months. 2. Weight stable for previous 6 months (+/-2.5 kg)
Exclusion criteria
1. Stage 2 hypertension (SBP \>/= 140 and/or DBP \>/= 90 mmHg) 2. BMI\>40 kg/m2 3. Diabetes 4. Familial hypercholesterolemia 5. Past or current history of CHD, stroke or major CVD events. Respiratory diseases (not including asthma), endocrine or metabolic, neurological, or hematological disorders that would compromise the study or the health of the subject. 6. Participants must not be pregnant, plan to become pregnant during the study, or be nursing 7. Active renal or liver disease 8. All medications and supplements that influence dependent variables\* 9. Recent surgery \< 2 months 10. Alcohol abuse 11. Sleep apnea
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulse wave velocity | 10 minutes before and 10 minutes after the exercise intervention |
Countries
United States
Contacts
Primary ContactTim Werner, PhD
Outcome results
None listed