Bronchial Endoscopy, Solid Cancer, Therapeutic Bronchofiberscopy
Conditions
Brief summary
Bronchoscopic endoscopy has shown its effectiveness and reliability for the treatment (desobstruction or prothesis) of tumor-induced bronchial obstructions, particularly in the first few weeks. The presence of a lower airway prosthesis can lead to device obstruction requiring daily inhaled fluidification, bacterial colonization, migration of the prosthesis, or the appearance of obstructive or hemorrhagic granulomas. The aim of this study is to evaluate the quality of life of patients after endobronchial treatment. It is a prospective, descriptive, and multicentric (national) study. The main objective is to compare the total score on the Saint-George questionnaire at J7 of the interventional endoscopy compared to before the procedure.
Interventions
PROCEDUREbronchoscope
procedure performed by bronchoscopy
Sponsors
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* \>18 years old * tumoral tracheobronchial obstruction and/or compression * proven solid cancer or suspicion * Acute respiratory distress (at least one of the 5): * RR : ≥25/min * Sign of respiratory struggle * Sign of respiratory failure * Oxygen therapy ≥5L/min * Ventilatory support (NIV, OHD or IT) : * Indication for therapeutic interventional endoscopy * No guardianship or curatorship * Non-hematological tumor
Exclusion criteria
* Minors * patients with neurological disabilities unable to understand and respond to the questionnaire * patients under guardianship or curatorship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Saint George Score (quality of life) | At inclusion, and 7 days after therapeutic bronchoscopy | Difference between Saint-George score at inclusion and Day 7. The scores for each dimension range from 0 to 100, with a score of 100 indicating excellent health. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ECOG-performance Status | inclusion and Day 30 | It ranges from 0 (fully active) to 5 (dead). |
| Duration of ventilatory support (mechanical ventilation, non-invasive ventilation, high-flow oxygen) | During the 30 first days from intervention | — |
| Saint-George and SF-12 (12-Item Short-Form Health Survey) score | at inclusion and Day 30 | Difference of these scores between inclusion and Day 30 The scores for each dimension of the Saint-George score range from 0 to 100, with a score of 100 indicating excellent health. The SF-12 score ranges from 1 to 60, with a score of 60 indicating very poor quality of life. |
| anti-tumoral treatment | During the 30 first days from intervention | initiation or continuation of anti-tumour treatment (radiotherapy, chemotherapy, immunotherapy, targeted therapy) |
| survival | through study completion, an average of 1 year | — |
| hospitalization duration | During the 30 first days from intervention | — |
Contacts
Primary ContactAnne-Claire Toffart, MD-PhD
Outcome results
None listed