How Healthy Are Your Oats?

Mycotoxin Biomonitoring

Human exposure, Toxicokinetics, Urinary excretion

Oat foods are commonly consumed as healthy breakfast options and their nutritional value is well recognised. Oats are a rich source of fibre, micronutrients and non-nutrient bioactive compounds, but at the same time cereals including oats can be contaminated with mycotoxins. To fully understand the nutritional benefits and potential food safety risks of oat consumption, this study aims to assess the nutritional composition of an oat food and the bioavailability of bioactive oat constituents and their metabolite profile in urine of volunteers consuming a single portion of an oat breakfast. This study requires 16 healthy volunteers to consume one portion of oats and collect their urine over 48 hours after the test meal. No other sample collection is required.

Cereal foods are important part of a healthy, balanced diet. Amongst cereals, oats form an important part of a Scottish diet and are an important agricultural commodity. Oats are well-known for their high nutritional value containing high-quality fatty acids (oleic and linoleic acids), proteins with high amino acid profiles and dietary fibre, most namely in the form of soluble β-glucans. These β-glucans have well-documented health benefits regarding cholesterol-lowering effects in humans. In addition to macronutrients, oats are also a rich source of micronutrients including tocopherols and a range of minerals. As such, the consumption of oats is highly recommended by dietary advice. However, oats and other cereals are also known to be at risk of contamination with naturally occurring fungal toxins called mycotoxins. Previous studies have demonstrated the presence of detectable levels of mycotoxins formed by Fusarium fungi in oat crops and oat foods. Current risk assessments by the European Food Safety Authority and the UK Food Standard Agency aim to establish maximum permitted levels of these mycotoxins in foods. The maximum levels aim to protect consumers from high level exposure and potential health effects. Rationale for Study This study is part of a wider programme of work investigating the health benefits and potential food safety risks of oats. The presence of phytochemicals and Fusarium mycotoxins in oat foods has been confirmed and the bioaccessibility of these bioactive compounds in the human gut has been demonstrated in-vitro. To fully quantify dietary exposure of individuals to these bioactive compounds, detailed work is needed to understand the rate of bioaccessibility of bioactive compounds from oat foods and their absorption and excretion into urine in humans. This detailed information will inform future studies aimed at assessing dietary exposure and risk. The proposed study aims to feed a single dose of an oat food to healthy volunteers. The study will assess how the oat food is digested and the bioactive compounds absorbed and excreted in vivo. The food will be selected to contain low and safe mycotoxin levels.

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United Kingdom