Aneurysmatic Subarachnoid Haemorrhage, Aneurysm Cerebral, Aneurysm, Ruptured, Arteriovenous Malformation of Central Nervous System
Conditions
Keywords
arteriovenous malformation, flow-related aneurysm, ruptured aneurysm, subarachnoid hemorrhage
Brief summary
AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.
Interventions
None listed
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT 2. No history of stroke, Marfan syndrome, polycystic kidney disease
Exclusion criteria
1. pAVM without flow-related aneurysms 2. Absence of clinical data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| characteristics of flow-related aneurysm | From enrollment to the end of treatment at 8 weeks | size ratio(aneurysm depth (mm)/parent artery diameter (mm)) |
Other
| Measure | Time frame | Description |
|---|---|---|
| demographic information of pAVM-rFA | From enrollment to the end of treatment at 8 weeks | gender |
| demographic information | From enrollment to the end of treatment at 8 weeks | age when be hospitalized |
| characteristics of flow-related aneurysm | From enrollment to the end of treatment at 8 weeks | aspect ratio (aneurysm depth (mm)/aneurysm neck (mm)) |
| characteristic of avm | From enrollment to the end of treatment at 8 weeks | avm location |
Countries
China
Contacts
Primary ContactYifei Wang
Outcome results
None listed