Body Temperature Regulation, Burn Injury, Cardiovascular Physiology
Conditions
Brief summary
Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.
Interventions
OTHERSimulated burn injury via application of absorbent and impermeable material over 60% of the body
Simulated burn injury via application of absorbent and impermeable material over 60% of the body
Sponsors
University of Texas Southwestern Medical Center
National Institute of General Medical Sciences (NIGMS)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 and 65 years of age * free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.
Exclusion criteria
* Known heart disease * other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening. * Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test. * Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response. * Current smokers, as well as individuals who regularly smoked within the past 3 years. * body mass index is ≥ 31 kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Core Temperature | From baseline to end of 60 minutes of recovery |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate | From baseline to the end of 60 minutes of recovery |
Countries
United States
Contacts
CONTACTErin M Harper, B.S.
CONTACTElizabeth A Gideon, PhD
PRINCIPAL_INVESTIGATORCraig G Crandall, PhD
University of Texas Southwestern Medical Center
Outcome results
None listed