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Risk Factors Affecting Mortality in Perforated Peptic Ulcer

Risk Factors Affecting Morbidity and Mortality in Perforated Peptic Ulcer

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07050199
Enrollment
85
Registered
2025-07-03
Start date
2022-04-01
Completion date
2023-03-30
Last updated
2025-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peptic Ulcers

Brief summary

Perforation is one of the most severe and life-threatening complications of peptic ulcer disease. This study aims to evaluate the risk factors associated with postoperative morbidity and mortality in patients undergoing surgery for peptic ulcer perforation, with a focus on the timing of presentation, demographic variables, surgical delay, and their association with postoperative outcomes.

Interventions

Emergency laparotomy

Sponsors

Maharajgunj Medical Campus
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
15 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Patients with peptic ulcer perforation aged\> 15 years and \<75 years. * Patients with duodenal or gastric perforation of peptic ulcer origin. * Patients who underwent simple closure with omental patch as a standard operative procedure.

Exclusion criteria

* Patients treated with conservative management. * Patients with perforation of peptic ulcer origin at the jejunum, ileum adjacent to Meckel's diverticulum. * Patients presenting with recurrent perforation or stomal ulcer perforation.

Design outcomes

Primary

MeasureTime frameDescription
Postoperative Morbidity Rate12 months (from patient enrollment to completion of follow-up)Incidence of postoperative complications (e.g., wound infection, sepsis, anastomotic leak, pneumonia) in patients undergoing surgery for perforated peptic ulcer.
Postoperative Mortality Rate12 months (from patient enrollment to completion of follow-up)Incidence of death following surgical intervention for perforated peptic ulcer.

Countries

Nepal

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026