Irrisept in Emergency General Surgery Patients

Effects of Irrisept Irrigation in Emergency General Surgery Cases on SSI Rates

Status

Enrolling by invitation

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07048899

Enrollment

400

Registered

2025-07-03

Start date

2024-09-04

Completion date

2026-04-30

Last updated

2025-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergency Surgery, Surgical Site Infections

Keywords

Irrisept, Surgical Irrigation, Surgical Site Infection, Emergency General Surgery, Acute Care Surgery, Normal Saline Irrigation

Brief summary

This is a single institution, randomized study conducted to determine if irrigation with Irrisept in emergency general surgery patients results in lower surgical site infections compared to normal saline irrigation.

Interventions

DRUGChlorhexidine

Intraperitoneal irrigation with Irrisept solution

DRUGNormal Saline

Intraperitoneal irrigation with normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All patients (>18 years old at time of enrollment) who are hospitalized at UT Tyler and undergo an open (or conversion to open) wound class 2-4 surgical procedure for an emergent surgical condition.

Exclusion criteria

* Those <18 years of age * Pressure wounds * Superficial abscesses (as primary diagnosis) * intra-abdominal abscess due to previous technical failure

Design outcomes

Primary

Measure	Time frame	Description
Surgical Site Infection Rate	Time of enrollment to 30 days	Determine if the rate of SSI is different

Secondary

Measure	Time frame	Description
Length of Stay	From date of admission until date of discharge from the hospital, assessed up to 30 days post-operatively	Number of days admitted to hospital
Incidence of SSI and surgical wound class with the use of Irrisept	Time of enrollment to 30 days	Correlation between surgical wound class and the use of Irrisept on the incidence of SSI
Readmission Rates due to SSI	From day of surgery to 30 days	How often a patient has to be re-admitted to the hospital for a surgical site infection

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026