Microlaryngeal Surgery
Conditions
Brief summary
compare effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and detect side effects of dexmedetomidine and ketamine.
Detailed description
Microlaryngeal surgery is a common surgical procedure now a days which is associated with many complications such as postoperative pain, airway edema and persistent cough . the study is to compare the effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and to detect side effects of dexmedetomidine and ketamine.
Interventions
DRUGDexmedetomidine
IV dexmedetomidine
DRUGKetamine
IV ketamine
DRUGSaline (control group)
no drugs
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 18-70 years ASA I,II
Exclusion criteria
* CVdiseases as IHD and severe valvular disease. * allergy to ketamine or dexmedetomidine. * Patients refusal * Suspected difficult intubation more than 2 trials
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of postoperative sore throat | 30 minutes postoperative | incidence of postoperative sore throat |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative cough incidence | 1hour postoperative | postoperative cough incidence |
| incidence of complications | 1hour postoperative | incidence of complications |
| Ramsey sedation score | 1hour postoperative | Ramsey sedation score RSS (1 to 6) |
| Mean Arterial Pressure | 1hour postoperative | Mean Arterial Pressure |
| oxygen saturation | 1hour postoperative | oxygen saturation |
| Heart Rate | 1hour postoperative | Heart Rate |
Countries
Egypt
Outcome results
None listed