Hashimoto Thyroiditis, Mediterranean Diet
Conditions
Keywords
Anti-TPO, Anti-TG, Hashimoto Thyroiditis, Mediterranean Diet, ThyPRO questionnaire
Brief summary
Hashimoto's thyroiditis (HT) is an autoimmune disease affecting the thyroid gland and is one of the most common causes of hypothyroidism. Eating habits may affect the risk of several inflammatory and immune diseases, such as HT. The current knowledge of the diet in HT is insufficient. The Mediterranean diet (MD) is an anti-inflammatory diet characterized by frequent consumption of olive oil, unrefined cereals, fresh or dried fruit and vegetables, moderate amounts of fish, dairy, and meat, and many condiments and spices. It is rich in nutrients and bioactives, which have the potential to offer anti-inflammatory aspects.
Detailed description
The investigators aimed to assess the impact of the Mediterranean diet on patients with Hashimoto thyroiditis using the following outcomes: Primary outcomes: Anti-TPO antibodies, Anti-Thyroglobulin antibodies, TSH, T3, T4 Secondary outcomes: BMI, Lipid profile, Symptoms of hypothyroidism
Interventions
DIETARY_SUPPLEMENTDietary modification
3-month dietary plan
Sponsors
Ain Shams University
Sherihan AboElyazed Mohamed Khalil
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patients with symptoms of hypothyroidism (hypothyroid/euthyroid) * Positive anti-thyroid antibodies (anti-TPO/anti-TG).
Exclusion criteria
* Pregnant or lactating females * Age below 20 years and above 50 years * presence of any other medical disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the serum level of anti-TPO and Anti-TG antibodies | after 3 months of dietary modification | IU/ml |
| Changes in the serum level of TSH | after 3 months of dietary modification | uIU/ml |
| Changes in the serum level of free T3 | after 3 months of dietary modification | pg/ml |
| Changes in the serum level of free T4 | after 3 months of dietary modification | ng/dl |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptoms of hypothyroidism | after 3 months of intervention | Thypro Scale |
| changes in BMI | after 3 months of intervention | kg/m\^2 |
| changes in serum level of total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein | after 3 months of intervention | mg/dl |
Countries
Egypt
Outcome results
None listed