Prenatal and Postnatal Ultrasonographic Evaluation of Myelomeningocele to Predict Post-Surgical Outcomes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07048691

Enrollment

Registered

2025-07-02

Start date

2025-03-17

Completion date

2026-02-28

Last updated

2025-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myelomeningocele

Brief summary

Myelomeningocele (MMC), also known as open spina bifida, is a serious congenital condition in which the cord and meninges protrude through the spinal column's defective bony encasement due to a defective closure of the posterior portion of the neural tube between the fourth week of pregnancy.

Detailed description

The formation of the defect is influenced by both genetic and environmental factors, while the exact cause is yet unknown. There is currently no effective treatment for this common and debilitating central nervous system (CNS) dysfunction.

Interventions

DIAGNOSTIC_TESTG.E HEALTHCARE ultrasound machine with high-resolution convex probe

After approval from the institutional ethical committee, a total number of patients presenting to the Radiology and Peads Neurosurgery department of Allied Hospital, Faisalabad, that met the inclusion criteria was selected. After obtaining informed consent from each patient and attendant of the patient, transabdominal ultrasound was examined longitudinal, transverse and oblique plans, ultrasound with a high- resolution convex probe was used by the radiologist

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

28 Weeks to 40 Weeks

Healthy volunteers

Inclusion criteria

* Gestational age 3rd trimester, Lesion between T1 and S1, Hindbrain herniation and Normal karyotype

Exclusion criteria

* Multiple gestation pregnancy * Other fetal anomalies unrelated to myelomeningocele * History of incompetent cervix, Other serious maternal medical conditions * Inability to adhere to travel and follow-up requirements * Contraindication to surgery and Inability to meet trial psychosocial criteria.

Design outcomes

Primary

Measure	Time frame	Description
self administered questioner	12 Months	self administered questioner for yelomeningocele patients scroing range fron 0-40. 0 is for lower and 40 is worse and higher

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026