Cardiac Biomarkers, Heart Rate Variability (HRV), Inflammatory Biomarkers, Long COVID
Conditions
Brief summary
Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.
Interventions
OTHERphysiothreapy protocol
Aerobic training (treadmill or exercise bike) for 15 minutes, anaerobic training at the weight training station, performing exercises for the upper limbs (bench press and front pull) and lower limbs (180º leg press and extension chair) with weight determined by the 1 Repetition Maximum (1RM) test, performing 3 sets of 12-15 repetitions (depending on the session) and respiratory muscle training using POWERbreathe (30-40% of the MIP performed in the manovacuometry test).
Sponsors
Universidade do Estado do Pará
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 59 Years
Healthy volunteers
No
Inclusion criteria
* both sexes * aged 20 and 59 years * clinical evaluation and undergoing clinical follow-up of Post COVID-19. * least one persistent COVID-19-related symptom.
Exclusion criteria
* incomplete data. * presence of a pacemaker * use of antihypertensive drugs that alter HRV * persistent pulmonary alterations * persistent desaturation * anaemia or presence of reinfection.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Autonomic Modulation | Before and afther the intervention 3 months. | cardiofrequency meter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammation | Before and the afther 3 months | the cardiac and inflammatory biomarkers, creatine phosphokinase isoenzyme MB (CKMB) associated with lactate dehydrogenase (LDH) and ferritin can be analysed. |
Contacts
Primary ContactLuiz Magno Falcão, Research and coordinator
Outcome results
None listed