Acute Ischemic Stroke (AIS), Endovascular Thrombectomy, Neurovascular Unit- Brain Lymphatic System
Conditions
Brief summary
The goal of this prospective cohort registration study is to establish an early warning system for futile recanalization in acute ischemic stroke by analyzing multi-omics information to identify key regulatory nodes and target molecules in ineffective recanalization. The core issue addressed by this research is: Identifying key regulatory nodes and target molecules closely associated with futile recanalization, revealing the interactions among the neurovascular unit, peripheral immune cells, and the brain lymphatic system, as well as developing early diagnostic biomarkers and novel diagnostic technologies for futile recanalization.
Interventions
None listed
Sponsors
National Science and Technology Major Project
Xijing Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 1\. Aged ≥18 years 2. Acute ischemic stroke confirmed by clinical and neuroimaging criteria (CT or MRI) 3. Clinical indication for thrombectomy 4. Provision of signed informed consent
Exclusion criteria
* 1\. Preexisting dementia or severe disability (modified Rankin Scale score ≥3) 2. Cerebral vascular malformations, neoplasms, abscesses, or other significant non-ischemic brain pathologies 3. Life-limiting systemic comorbidities (e.g., end-stage organ failure, metastatic malignancies) with anticipated survival \<6 months 4. Patient or legally authorized representative declined consent 5. Anticipated poor protocol adherence or loss to follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-month mRS score | From enrollment to the end of treatment at 3 months |
Other
| Measure | Time frame |
|---|---|
| All-cause mortality within 3 months | From enrollment to the end of treatment at 3months |
Countries
China
Outcome results
None listed