COPD
Conditions
Keywords
FeNO, Blood eosinophil count, COPD
Brief summary
This study aims to evaluate how airway inflammation, lung function, and symptoms change over time in people with chronic obstructive pulmonary disease (COPD). Airway inflammation will be assessed using a simple breath test (FeNO) and a small blood sample to measure eosinophils, a type of white blood cell. Participants will be followed for one year, with three study visits (at the start, 6 months, and 12 months). The goal is to understand how these markers evolve and whether they differ between people who experience a worsening of symptoms (called exacerbations) and those who remain stable. All tests except for a small extra blood draw are part of routine COPD care. Participation does not affect standard treatment.
Interventions
DIAGNOSTIC_TESTBlood eosinophil Count
Blood sample for blood eosinophil count
Sponsors
Universitair Ziekenhuis Brussel
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged ≥ 40 years * Diagnosed with COPD according to GOLD criteria * Attending routine follow-up visits every 6 months * Ability to provide informed consent
Exclusion criteria
* Recent respiratory tract infection or exacerbation (either moderate or se-vere) (\<4 weeks before inclusion) * Dominant asthmatic phenotype (ACO with asthma predominance) * Severe comorbidities interfering with participation or follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the longitudinal stability of FeNO levels in COPD patients over a 12-month period with biannual measurements. | from enrollment to the end of the study period (1 year) |
Countries
Belgium
Contacts
Primary ContactNaomi Michotte, MD
Outcome results
None listed