Assessment the Effectiveness of BTVA in COPD and Ablation in Pulmonary Nodules by Pulmonary MRI

Assessment the Effectiveness of Bronchoscopic Thermal Vapor Ablation in Chronic Obstructive Pulmonary Disease and Ablation in Pulmonary Nodules by Pulmonary Magnetic Resonance Imaging

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07045532

Enrollment

100

Registered

2025-07-01

Start date

2024-09-01

Completion date

2026-09-30

Last updated

2025-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Lung Cancers

Keywords

MRI, COPD, Lung cancer, ablation

Brief summary

A Clinical Study Based on Magnetic Resonance Imaging of the Lungs to Assess the Efficacy of Thermal Vapor Ablation and Pulmonary Nodule Ablation in Chronic Obstructive Pulmonary Disease After Surgery. The efficacy of hot steam ablation for chronic obstructive pulmonary disease was evaluated using the innovative MRI sequence PREFUL\_MRI, and the efficacy of pulmonary nodule ablation was evaluated using the innovative MRI sequence GRASP\_MRI.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Age \>18 years old; 2. Patients with pulmonary nodules: patients with pulmonary nodules indicated by chest CT, pathologically diagnosed as malignant, and receiving ablative treatment, including transthoracic and percutaneous ablative methods, including radiofrequency, microwave, and freezing; 3. COPD patients: patients diagnosed with COPD according to the GOLD principle and treated with thermal steam ablation for COPD; 4. Understand the study and sign the informed consent.

Exclusion criteria

1. Chest CT nodules in patients with pulmonary nodules were pure ground glass nodules; 2. Patients who install or carry metal implants such as cardiac pacemakers, heart stents, artificial heart valves in the body or suffer from claustrophobia, allergy to contrast media and other reasons are not suitable for MRI examination; 3. severe cardiopulmonary dysfunction and other diseases that may significantly increase the risk of ablation surgery; 4. Patients with severe COPD exacerbation or pneumonia in the past four weeks;

Design outcomes

Primary

Measure	Time frame	Description
PREFUL-MRI Ventilation and Perfusion Parameters in Patients with COPD Following Lung Volume Reduction Surgery with Thermal Steam	From enrollment to 6 months post-surgery	Using the Phase-Resolved Functional Lung(PREFUL)-MRI dedicated post-processing analysis software, we can obtain images of the patient's lung ventilation and perfusion status.
Quantitative Hemodynamic Analysis Parameters Based on Tofts Model Using GRASP-MRI After Ablation of Solid Pulmonary Nodules	From enrollment to 3 months post-surgery	Quantitative parameters of GRASP-MRI images based on the Tofts model: Volume transfer coefficient(Ktrans)(/min)：the rate transfer constant of gadolinium between plasma and tissue interstitium;

Countries

China

Contacts

Primary ContactLin Ye, MD

sjtuyl@163.com021-62821990

Backup ContactJiayuan Sun, MD, PhD

xkyyjysun@163.com021-62821990

Outcome results