Uric Acid
Conditions
Keywords
uric acid, female, non cardiac, acute kindeny injury, menopause
Brief summary
Preoperative serum uric acid significantly impacted acute kidney injury in female patients undergoing non-cardiac surgery, with differential effects observed before and after menopause.
Detailed description
Preoperative serum uric acid has been increasingly recognized as a potential biomarker associated with acute kidney injury in various clinical settings. However, the sex-specific and hormonal influences on this association remain unclear, particularly in the context of non-cardiac surgery. Female patients, who experience significant physiological changes across the menopausal transition, may exhibit different renal susceptibilities to elevated serum uric acid levels. In this retrospective cohort study, the investigators aimed to evaluate the association between preoperative serum uric acid levels and postoperative acute kidney injury in female patients undergoing non-cardiac surgery, with a particular focus on menopausal status. Women were stratified into premenopausal and postmenopausal groups based on age and clinical criteria. The investigators hypothesized that the threshold and pattern of serum uric acid-associated acute kidney injury risk may differ between these two populations due to differences in hormonal status and baseline renal reserve.
Interventions
OTHERNo Intervention: Observational Cohort
This observational cohort includes female patients undergoing non-cardiac surgery. No intervention was administered as part of the study protocol. Preoperative serum uric acid levels were measured, and patients were followed for the development of postoperative acute kidney injury. Data were analyzed retrospectively to assess the association between uric acid levels and acute kidney injury, with subgroup analyses based on menopausal status (premenopausal vs. postmenopausal women).
Sponsors
Asan Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Inclusion criteria
* Female patients aged 18 years and older who underwent elective non-cardiac surgery
Exclusion criteria
* Patients with gout * Patients who underwent nephrectomy or kidney transplantation (either as recipients or donors) * Patients diagnosed with chronic kidney disease or who had already undergone kidney replacement therapy * Patients with estimated glomerular filtration rate \< 30 mL/min/1.73m²; and patients with incomplete data or missing laboratory values
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative Acute Kidney Injury | 7 days post-surgery |
Countries
South Korea
Outcome results
None listed