Migraine
Conditions
Keywords
chronic migraine, drug-resistant migraine
Brief summary
The main goal of this study is to find out how well middle meningeal artery coil embolization works for patients with recurrent chronic migraines that are not resolved with medication.
Detailed description
This study seeks to evaluate the therapeutic potential of middle meningeal artery coil embolization as an interventional strategy for patients with recurrent and pharmacoresistant chronic migraine. Middle meningeal artery embolization has recently gained recognition as a safe and effective intervention for the management of chronic subdural hematoma, demonstrating a low complication profile. The procedure achieves therapeutic effect by reducing or occluding arterial flow within the middle meningeal artery, thereby minimizing arterial dilatation and facilitating hematoma resorption over time.
Interventions
PROCEDUREMiddle Meningeal Artery Embolization
Middle meningeal artery embolization using particles or coils
Sponsors
Wake Forest University Health Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with diagnosis of migraine with or without aura, chronic migraine, unilateral or bilateral, moderate to severe intensity, 4-72 hours, familiar or sporadic, status migrainosus, primary or secondary * Patient who failed pharmacologic treatment (at least 2 failed drugs treatment for more than 3 months) or have considerable side effects * Patient with diagnosis of migraine and preference for embolization treatment * Clinical follow up of at least 3 months * Baseline computed tomography head (CTH) or MR brain which rule out additional intracranial pathology (patient with baseline intracranial pathology other than migraine will be excluded; see the
Exclusion criteria
section below) * Presence of patent middle meningeal artery homolateral to the side of migraine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Migraine Disability Assessment (MIDAS) | Baseline | The MIDAS is a 7 item survey. Score range is Grade I-IV with a higher score indicating severe disabling headache. |
| Migraine Pain Scale | Baseline | Migraine pain scale range is 1-10 with a higher indicating severe level of pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Pain Meds Used Post Procedure | 1 Hour Post Procedure | Number of pain meds used by participant post embolization procedure |
Contacts
PRINCIPAL_INVESTIGATORHamad Farhat, MD
advocate christ medical center
Outcome results
None listed