Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery

Comparison of Individualized PEEP Application Versus Fixed PEEP Application for Lung-Protective Ventilation in Patients Undergoing On-Pump Coronary Artery Bypass Grafting Surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07044089

Enrollment

Registered

2025-06-29

Start date

2025-07-23

Completion date

2027-09-01

Last updated

2026-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peep Titration in Lung Protective Ventilation

Keywords

Lung Protective Ventilation, Fixed PEEP, Individualized PEEP

Brief summary

Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery. Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.

Detailed description

The primary goal of the researchers: To compare the effects of fixed PEEP versus driving pressure guided individualized PEEP in lung protective mechanical ventilation during on-pump open heart surgery effect of PaO2/ FiO2 ratio end of surgery. The secondary goals of the researchers: To compare intraoperative hemodynamics, lung compliance and airway pressures, extubation time and respiratory complications \[development of atelectasis, need for noninvasive mechanical ventilation (high-flow nasal cannula or CPAP application), need for re-intubation\], length of stay in the ICU and discharge times.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy * Patients between the ages of 18 and 70 * ASA (American Society of Anesthesiologists) physical status classification II-III

Exclusion criteria

* Patients with an ejection fraction below 35% * Patients who did not consent to participate in the study * Patients undergoing emergency surgery * Patients who are allergic to the anesthetic drugs used * Patients who have undergone lung resection * Those with a history of mechanical ventilation in the 2 months before surgery * Patients who have undergone total circulatory arrest and deep hypothermia * Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance * Morbid obesity (Body Mass Index\>35kg/m2) * Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation) * COPD (FEV1\<70%) * Patients with chronic renal failure (serum creatine\>1.8 mg/dl) * Anemia (Hg\<10 gr/dl) * Patients who have had an intraaortic balloon pump placed.

Design outcomes

Primary

Measure	Time frame	Description
Effects on intraoperative oxygenation, hemodynamics, lung compliance and airway pressures	First one day	Data will be recorded during surgery and the first 24 hours after extubation.

Countries

Turkey (Türkiye)

Contacts

CONTACTZeynep Açık, MD

zeynebacik96@gmail.com+905077367990

CONTACTTülay Çardaközü, PROFESSOR

tulayhosten@hotmail.com+905323262342

Outcome results