Cerebral Infarction
Conditions
Keywords
cerebral infarction, thrombus, stroke mechanism, prognosis
Brief summary
Patients with acute ischemic stroke who have undergone endovascular thrombectomy will be eligible to be included, and thrombus will be collected after obtaining informed consent. Enrolled patients will receive a comprehensive diagnostic evaluation and the best medical treatment according to recent stroke management guidelines. The mechanism of the stroke will be classified into atherosclerotic, cardiac embolism, others and unknown causes based on diagnostic workup. Patients will be monitored in an outpatient clinic for vascular events including stroke recurrence, death, and bleeding events, which will continue for up to two years after the initial stroke event. Thrombus information related to RNA expression patterns and histological characteristics will be analyzed to classify the stroke mechanism and predict future vascular events after the initial stroke.
Interventions
DIAGNOSTIC_TESTthrombus analysis
Detailed expression pattern of RNA and histological characteristics will be investigated.
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients with acute ischemic stroke who had undergone endovascular thrombectomy
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular events | two years after initial stroke | major vascular events after endovascular thrombectomy, including stroke, myocardial infarction, and vascular death |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thromboembolic events | two years after initial stroke | Any thromboembolic events after endovascular thrombectomy including ischemic stroke, transient ischemic attack, myocardial infarction or unstable angina, peripheral artery disease requiring hospitalization, venous thromboembolism, pulmonary embolism and vascular death |
Other
| Measure | Time frame | Description |
|---|---|---|
| overall mortality | two years after initial stroke | any death event after endovascular thrombectomy |
Countries
South Korea
Outcome results
None listed