Systemic Lupus Erythematosus Disease
Conditions
Brief summary
This study aims to evaluate the clinical utility of combining the albumin to globulin ratio (AGR) and the prognostic nutritional index (PNI) as a predictive model for assessing disease activity in patients with systemic lupus erythematosus (SLE). By correlating these nutritional and inflammatory markers with clinical manifestations and laboratory parameters, we hope to establish a simple, non-invasive, and cost-effective tool to aid in monitoring disease activity in Systemic lupus erythematosus patients.
Interventions
DIAGNOSTIC_TESTAlbumin to globulin ratio and prognostic nutritional index model
Measurement of albumin to globulin ratio and prognostic nutritional index in participants to assess disease activity in systemic lupus erythematosus patients
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* · Age ≥ 18 years. * Both sexes. * Patients diagnosed with SLE who fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and matched controls.
Exclusion criteria
* Co-existing chronic inflammatory or autoimmune diseases. * Age \<18 years * Malignancy. * Pregnancy or lactation. * Chronic liver or renal insufficiency. * Malignant hematologic diseases. * Active hepatitis. * Acute infection within the previous four weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| assess the utility of the albumin-to-globulin ratio (AGR) as reliable, non-invasive biomarker for predicting disease activity in patients with systemic lupus erythematosus (SLE). | From 6 month to one year |
Countries
Egypt
Contacts
CONTACTHala A Hamid, Master
CONTACTEsam M Abualfadl, Professor
STUDY_CHAIREsam M Abualfadl, Professor
Sohag University
STUDY_DIRECTORRabab H Ali, MD
Sohag University
Outcome results
None listed