Risk Factors for Microvascular Obstruction Post-Emergency PCI in AMI Patients

Triglyceride Glucol Index for Predicting the Value of No-Reflow in Patients Undergoing Emergency PCI for Acute Myocardial Infarction

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07042321

Enrollment

300

Registered

2025-06-29

Start date

2024-06-01

Completion date

2025-08-31

Last updated

2025-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction (AMI)

Brief summary

The goal of this prospective cohort study is to investigate the relationship between the TyG index and early identification of MVO in AMI patients undergoing emergency PCI and CMR imaging. The study will enroll approximately 300 AMI patients treated at Xiangya Third Hospital of Central South University from June 2024 to August 2025. The main questions it aims to answer are: * How does the TyG index correlate with the early detection of MVO? * What differences in cardiovascular adverse events during hospitalization exist between groups with varying TyG index levels? Participants will undergo emergency PCI and CMR imaging within 3-7 days post-procedure. Data collected will include demographic characteristics, clinical history, coronary angiography data, laboratory test indicators (especially metabolic markers such as blood glucose and lipids), IVUS-related plaque information, and CMR results.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 18 years. * STEMI symptom onset time \< 12 hours. * STEMI symptom onset time 12-48 hours, with ongoing ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias. * Very high-risk NSTEMI; undergoing emergency PCI treatment. * Voluntary signed informed consent form.

Exclusion criteria

* Non-obstructive acute myocardial infarction. * Severe chronic kidney disease (defined as estimated glomerular filtration rate \<20 mL/min per 1.73 m²). * Pregnant women or those planning to become pregnant. * Failure of emergency PCI. * Unclear CMR images

Design outcomes

Primary

Measure	Time frame
The presence or absence of microvascular obstruction (MVO) diagnosed by cardiac magnetic resonance (CMR) within 3-7 days postoperatively	3-7 days postoperatively

Countries

China

Contacts

Primary Contactcan Zhu Can

zhucan1021@163.com+8613348674820

Outcome results