Microvascular Profiling of Nodules in the Thyroid Gland

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07041307

Enrollment

Registered

2025-06-27

Start date

2025-08-15

Completion date

2028-12-31

Last updated

2025-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Nodular Disease

Keywords

thyroid nodules, super-resolution ultrasound

Brief summary

The purpose of this study is to examine tiny blood vessels in different thyroid nodules using advanced ultrasound. In the long term, we hope this can help doctors better tell the difference between types of nodules and more accurately decide who may need surgery.

Detailed description

In this study, the investigators use an advanced ultrasound technique called Super-Resolution Ultrasound of Erythrocytes (SURE) to map the microvasculature in the thyroid gland and thyroid nodules. This method provides much higher resolution than conventional ultrasound, allowing us to visualize and measure even the smallest blood vessels. The investigators aim to explore whether this technique can help differentiate between various types of thyroid nodules - including benign and malignant - and possibly between hyper-, iso-, and hypofunctioning nodules, based on their microvascular characteristics.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age over 18 years * Written and verbal informed consent to participate in the study * Patients with hypo-, iso-, or hyperfunctioning thyroid nodules * Patients referred for thyroid surgery due to suspected malignant nodule (including Bethesda classification groups III, IV, V, and VI) * Healthy volunteers - generally good health with no chronic illnesses

Exclusion criteria

* Pregnancy * Inability to undergo the examination due to physical or mental limitations * Desire to opt out of receiving information about new, significant health findings revealed during the study * Healthy Participants: * Thyroid disease, including nodules, as well as current or past conditions affecting the thyroid * Medication that affects thyroid function

Design outcomes

Primary

Measure	Time frame	Description
Visualization of the Microvasculature in the Thyroid Gland and Thyroid Nodules	30 minutes	With super-resolution ultrasound imaging using the erythrocytes, the investigators will visualize the microvasculature in normal thyroid tissue and different types of thyroid nodules.

Secondary

Measure	Time frame	Description
Quantification of the Microvasculature	30 minutes	Quantification of the thyroid microvasculature and the microvasculature in thyroid nodules. This includes vessel density, vessel diameters, blood flow velocity and vessel distribution.

Countries

Denmark

Contacts

Primary ContactNathalie Sarup Panduro, MD

nathalie04@gmail.com+4529273193

Backup ContactMichael Bachmann Nielsen, Professor PhD dr.med.

mbn@dadlnet.dk+4535458233

Outcome results