Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07039500

Enrollment

100

Registered

2025-06-26

Start date

2024-12-11

Completion date

2025-12-10

Last updated

2025-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Auditory Processing Disorder, Obstructive Sleep Apnea

Keywords

Obstructive Sleep Apnea, Auditory Cognition, Electroencephalography (EEG), Oddball Paradigm

Brief summary

The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are: 1. Does severe OSAHS change how the brain automatically detects sound changes during wakefulness? 2. Does severe OSAHS reduce people's ability to pay attention to important sounds when awake? 3. Can brainwave tests (Electroencephalogram, EEG) detect early signs of hearing-related cognitive problems in OSAHS patients before symptoms appear? Researchers will compare two groups: * 50 adults with severe OSAHS (diagnosed by sleep tests) * 50 healthy adults matched by age and gender Participants will: * Complete hearing tests (MoCA) * Undergo a 1-night sleep test (PSG) * Wear an EEG cap for 1.5-2 hours while listening to sounds in a quiet room: * Passive task: Relax (no response needed) * Active task: Press a button when hearing rare sounds * Receive ¥75/hour compensation for their time

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

All Participants: * Aged 20-60 years * Normal hearing (PTA ≤25 dB HL at 0.5,1,2,4 kHz; Type A tympanogram) * MoCA score ≥26 * Willing to complete EEG testing OSAHS Group Additional: \- PSG-confirmed severe OSAHS (AHI \>30 events/hour) Control Group Additional: * Self-reported absence of snoring/sleep disorders * No prior OSAHS diagnosis

Exclusion criteria

All Participants: * History of: * Schizophrenia, epilepsy, Parkinson's, TBI, or language disorders * Middle/inner ear diseases (otitis media, acoustic neuroma, etc.) * Cognitive impairment or depression/anxiety disorders * Chronic steroid use * Systemic inflammatory diseases or malignancies * Pregnancy or suspected pregnancy (self-reported)

Design outcomes

Primary

Measure	Time frame	Description
Amplitude of Mismatch Negativity (MMN)	Day 1	EEG-derived MMN amplitude (microvolts, μV) during oddball task. Lower values indicate impaired automatic sound change detection.
Latency of Mismatch Negativity (MMN)	Day 1	EEG-derived MMN latency (milliseconds, ms) during oddball task. Longer values indicate slower automatic processing.

Secondary

Measure	Time frame	Description
Reaction Time in Active Auditory Oddball Task	Day 1	Time taken to press button after deviant sound onset (milliseconds). Higher values indicate slower processing speed.
Accuracy in Active Auditory Oddball Task	Day 1	Percentage of correct button presses to deviant sounds (%). Lower values indicate worse performance.
Inter-Trial Phase Coherence (ITPC) in Theta/Alpha/Beta Bands	Day 1	EEG oscillatory synchronization (range 0-1; 0=no phase consistency). Lower values indicate neural desynchronization during auditory processing.

Countries

China

Contacts

Primary ContactCaifeng Xia, M.D.

xiacf@pku.edu.cn+8618811173785

Outcome results