Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain

Comparison of Interlaminar CT Guided Epidural Platelet Rich Plasma Versus Steroid Injection in Patients With Lumbar Radicular Pain : a Prospective Study With Long Term Follow up

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07036445

Enrollment

200

Registered

2025-06-25

Start date

2025-09-11

Completion date

2028-12-31

Last updated

2025-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Herniated Disc

Brief summary

The treatment of persistent lumbar radicular pain (LRP) using CT-guided epidural steroid injection (ESI) is widely used and associated with rare but serious complications. Platelet-rich plasma (PRP), which has recently been shown to promote healing and the anti-inflammatory process by delivering growth factors and cytokines, could be an alternative and potentially safer option. A previous study showed that PRP was as effective as ESI in treating this condition, without major complications. This study aims to compare these two treatments over the long term (2 years).

Interventions

PROCEDUREEpidural Steroid Injection

Intervention consists of interlaminar CT guided epidural steroid injection

PROCEDUREEpidural platelet-rich plasma injection

Intervention consists of interlaminar CT guided epidural platelet-rich plasma injection after recovery of plasma by blood sampling and centrifugation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diagnosis of unilateral resistant LRP associated with a herniated disc on MRI images. (Diagnosis of resistance after 6 weeks of appropriate medical treatment).

Exclusion criteria

* Patients with infections, * Patients who have had previous percutaneous corticosteroid injections, * Patients undergoing systemic corticosteroid treatment, * Patients with immune deficiencies, * Patients who are allergic to the contrast medium used, * Pregnant or breastfeeding patients, * Patients with a history of allergies to anesthetics or corticosteroids, * Anticoagulant treatment or blood disorders, patients on antiplatelet therapy * Taking NSAIDs within two weeks prior to the procedure

Design outcomes

Primary

Measure	Time frame	Description
Functional ability	30 minutes before procedure ; 6 weeks after procedure ; 6 months, 1 year, 2 years after procedure	Oswestry Disability Questionnaire ranging from 0 to 100%

Secondary

Measure	Time frame	Description
Pain evaluation	6 weeks, 6 months, 1 year and 2 years after procedure	Numerical pain rating scale (NRS): intensity of combined pain in the legs and back ranging from 0 to 10

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026