Anesthesia, Pregnancy Complications
Conditions
Keywords
Propofol, Pregnancy, Cesarean delivery, Perinatol outcome
Brief summary
The effects of intravenous propofol administration for general anesthesia in cesarean deliveries on maternal and infant health will be evaluated in relation to maternal and umbilical cord blood propofol levels.
Detailed description
After the ethics committee approval was obtained, volunteers who met the criteria for inclusion in the study were included in the study after obtaining their written permission. After the patients were taken to the operating room, IV catheterization was achieved after CTA, TA and sPO2 monitoring, and the patient was intubated 2 minutes after induction of propfol at 3 mg/kg and rocuronium at 0.6 mg/kg. After the baby was born, an intravenous blood sample was taken from the umbilical cord and the mother simultaneously. After the venous blood samples were obtained as 3 μL, the serum samples obtained by centrifugation as standard were portioned in equal volume to 500 μL Eppendorf tubes and stored at -80°C. After this pre-treatment, propofol was subjected to measurement tests with HPLC, and the collected data were added
Interventions
DRUGCaesarean Section
Cesarean section was performed as routine surgical procedure
Sponsors
Haseki Training and Research Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Observational
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Being pregnant in ASA category 1-2 * \>39 weeks of healthy pregnancy * \>28 weeks complicated pregnancy * Cesarean delivery with or without action * Providing induction of general anesthesia with intravenous propofol
Exclusion criteria
* Pregnant women under the age of 18, * Those who have stillbirth, * Severe chronic kidney and liver disease, * Neurological disease * Those with other systemic diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood propofol concentration | The first 5 minutes of cesarean delivery | ng/ml |
Countries
Turkey (Türkiye)
Outcome results
None listed