Bronchial Response to Exercise After Double Lung Transplantation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07035743

Enrollment

Registered

2025-06-25

Start date

2025-06-05

Completion date

2025-12-31

Last updated

2025-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Airway Response, Challenge Test, Lung Transplant, Lung Transplant Recipients

Keywords

airway response, double lung transplantation, exercise challenge test, dyspnea, breathlessness

Brief summary

This study aims to investigate the airway response to exercise and its association with breathlessness in double lung transplant recipients by comparing responses during 5-minute and 15-minute exercise durations.

Detailed description

Participants will undergo a constant workload challenge set at 60% of their peak oxygen uptake in 2 separate sessions: a 5-minute and a 15-minute exercise session, conducted in a random order. Ratings of perceived exertion will be measured every 5 minutes during exercise. Forced expiratory volume in 1 second will be performed before exercise, immediately post-exercise, and at 5, 10, 15, 20, and 30 minutes post-exercise in order to assess the airway response.

Interventions

OTHERExercise

5 minutes of constant workload exercise at 60% of peak oxygen uptake from cardiopulmonary exercise testing

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Received double lung transplantation 2. ≥ 3 months post-transplant

Exclusion criteria

1. Diagnosis of asthma 2. Significant airflow limitation (≤50% FEV1 predicted) 3. Inability to cooperate with the required tests and measurements 4. Recent infection or rejection within 1 month 5. Exercise contraindication (e.g., recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, malignant arrhythmias)

Design outcomes

Primary

Measure	Time frame	Description
Percentage change in FEV1 from baseline	from enrollment to up to 12 weeks	Percentage change in FEV1 from baseline at immediately post-exercise, 5, 10, 15, 20, and 30 minutes post-exercise.

Countries

Taiwan

Contacts

Primary ContactMei-Chun Wan

alliewan@cgmh.org.tw+886-3-3281200

Backup ContactMei-Chun Wan

r10428001@ntu.edu.tw+886-3-3281200

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026