Post Spinal Hypotension
Conditions
Brief summary
Comparing ketamine and ephedrine to decrease the incidence of post spinal hypotension after caesarean section delivery.
Detailed description
To compare the effect of ketamine versus ephedrine in decreasing the incidence of hypotension in caesarean section delivery a study group including 50 participants will receive ketamine and 50 group will receive ephedrine after the consent and detailed history the two groups will receive preload of 500ml enter acetate then dormicum for sedation then spinal anesthesia will be performed initial blood pressure and heart rate will be measured then every five minutes
Interventions
DRUGKetalar
women receiving sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml of normal saline.
DRUGEphedrine
women receiving bolus of 15mg of ephedrine
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients undergoing Caesarian Section under spinal anesthesia, * Patients aged 18-45 years, * At term (≥37-week gestation), * American Society of Anaesthesiologists (ASA) physical status 1 or 2
Exclusion criteria
* Pre-eclampsia, * Chronic hypertension, cardiovascular troubles, * Any contraindication to regional anesthesia such as local infection or bleeding disorders, * Any hypersensitivity to ketamine. * Declined informed consent. * American Society of Anaesthesiologists (ASA) physical status lll or lV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of hypotension post spinal in CS | From injection till the end of surgery | For ketamine Group: women receiving sub-anesthetic dose of ketamine of 0.5 mg/kg IV bolus in 3 ml of normal saline. ( Reves JG et al,2010 ) * For ephedrine Group: women receiving bolus of 15mg of ephedrine * All the patients will receive 2 mg midazolam IV directly after delivery of the fetus.( Perumal DK et al ) * Heart Rate (HR) and Mean Arterial Blood Pressure (MAP) will be recorded at baseline 5 minutes prior to the intrathecal injection and 5 minutes, 10 minutes, 15 minutes, and 20 minutes after the injection and then every 15 minutes till the end of the operation. * Incidence of hypotension will be recorded which is defined as MAP less than 20% below the baseline or was ≤ 65 mmHg. Incidence of severe hypotension ≤ 50 mmHg will be recorded. |
Countries
Egypt
Outcome results
None listed