Inhospital Cardiac Arrest, Out of Hospital Cardiac Arrest
Conditions
Keywords
cardiac arrest, Skeletal muscle mass, rehabilitation
Brief summary
The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. The model will be validated using multicenter registry data and medical imaging. Furthermore, a clinical trial involving core muscle rehabilitation for post-resuscitation patients will be conducted to evaluate both short-term and long-term outcomes, aiming to comprehensively understand the impact of muscle mass on the prognosis of patients after cardiac arrest.
Interventions
BEHAVIORALEnhanced Rehabilitation Program
Participants in the intervention group receive an enhanced rehabilitation program, including muscular electrical stimulation, guided active rehabilitation sessions, and structured physical engagement during periods of consciousness. The intervention is designed to promote functional improvement in post-cardiac arrest patients.
Sponsors
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Intervention model description
This is a parallel assignment trial in which participants are allocated to study arms based on the month of admission. Patients admitted during even-numbered months are assigned to the intervention group, while those admitted during odd-numbered months are assigned to the control group.
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Non-traumatic adult patients who experienced sudden cardiac arrest * Achieved sustained return of spontaneous circulation (ROSC) for more than five minutes following successful resuscitation * Admitted to the ICU * Survived beyond 72 hours without successful weaning from mechanical ventilation
Exclusion criteria
* Age under 18 years * Pregnancy * Expected to be weaned from mechanical ventilation within 48 hours * Terminal-stage cancer or unwillingness to receive aggressive treatment * Unavailability of ICU care due to overcrowding in the emergency intensive care unit * Refusal to participate in the study by the patient or family members * Presence of an implanted pacemaker or defibrillator * Open wounds, severe edema, or deep vein thrombosis in the lower limbs * Pre-arrest status limited to wheelchair use or bedridden, unable to ambulate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| skeletal muscle mass | 21 days | Muscle changes were measured weekly using a handheld ultrasound. |
Countries
Taiwan
Outcome results
None listed