Dialysis; Complications, Performance Enhancing Product Use
Conditions
Keywords
dialysis, poor physical performance, creatine, body composition, Short Physical Performance Battery (SPPB), handgrip test
Brief summary
Adult patients undergoing chronic dialysis therapy for at least three months were selected. A physical function assessment was conducted, including the Short Physical Performance Battery (SPPB) and a handgrip strength test. Additionally, a bioelectrical impedance analysis was performed. Subsequently, 5 grams of creatine were administered daily for a period of eight weeks, after which the same assessments were repeated. The results were then analyzed to identify any differences in the tests, aiming to detect potential changes following creatine supplementation.
Detailed description
Adult patients undergoing chronic dialysis therapy for at least three months were selected, primarily based on their good adherence to pharmacological and dialysis treatment regimens. A physical function assessment was conducted, including the Short Physical Performance Battery (SPPB) and a handgrip strength test. Additionally, a bioelectrical impedance analysis was performed. All participants were informed that creatine would be administered and provided written informed consent. The study protocol was approved by the local ethics committee. Creatine supplementation consisted of 5 grams per day for eight weeks. On dialysis days, the dose was administered immediately after the dialysis session. On non-dialysis days, patients were responsible for self-administering the creatine at home. The creatine was diluted in 100 mL of water before ingestion. All assessments were conducted the day following the second dialysis session of the week-on Thursday or Friday, depending on the patient's schedule. There was no control group so pre-creatine measurements were considered as the basal (control) state. Measurements were taken before and after the creatine supplementation period in the same patients. The data were analyzed to evaluate changes in the outcomes following creatine use.
Interventions
DIETARY_SUPPLEMENTCreatine
Five grams of creatine were administered to each patient daily for eight weeks.
Sponsors
Carla Basualto Alarcón
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Functional assessments and bioelectrical impedance analysis conducted pre- and post-creatine supplementation
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Eligible to provide informed consent * At least three months on chronic dialysis therapy * No physical impairments that would prevent completion of the SPPB or bioelectrical impedance analysis
Exclusion criteria
* Pregnancy * Use of any nutritional supplement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Compare Short Physical Performance Battery (SPPB) before and after 8 weeks of creatine use | eigth weeks | To compare the physical functionality status of selected patients, as assessed by the Short Physical Performance Battery (SPPB), before and after eight weeks of creatine supplementation. Scale range between 0-12 points. Higher points mean a better outcome (higher physical functionality). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compare body composition: skeletal muscle mass, estimated by bioimpedance analysis before and after eight weeks of creatine supplementation | eigth weeks | Compare changes in skeletal muscle mass (Kg), estimated by bioimpedance analysis before and after eight weeks of creatine supplementation |
| Compare body composition: fat free mass, estimated by bioimpedance analysis before and after eight weeks of creatine supplementation | eigth weeks | Compare changes in fat free mass (Kg), estimated by bioimpedance analysis before and after |
| Compare body composition: total body water (Lt), estimated by bioimpedance analysis before and after eight weeks of creatine supplementation | eigth weeks | Compare changes in tota body water (Lt), estimated by bioimpedance analysis before and after |
| Compare hand grip strength as assessed by a hand dynamometer, before and after eight weeks of creatine supplementation | eigth weeks | compare changes in muscle strength, measured using a hand dynamometer. |
| Compare body composition: intracellular water (Lt), estimated by bioimpedance analysis before and after eight weeks of creatine supplementation | eigth weeks | Compare changes in intracellular water (Lt), estimated by bioimpedance analysis before and after |
| Compare body composition: phase angle (degrees), estimated by bioimpedance analysis before and after eight weeks of creatine supplementation | eigth weeks | Compare changes in phase angle (degrees), estimated by bioimpedance analysis before and after |
| Compare body composition: extracellular water (Lt), estimated by bioimpedance analysis before and after eight weeks of creatine supplementation | eigth weeks | Compare changes in extracellular water (Lt), estimated by bioimpedance analysis before and after |
Countries
Chile
Outcome results
None listed