Echocardiography, Transcatheter Aortic Valve Replacemen
Conditions
Brief summary
Conventional transcatheter aortic valve replacement (TAVR) relies on fluoroscopic and contrast agents. However, in high-risk patients, exposure to ionizing radiation and contrast agents is contraindicated and undesirable. Echocardiography guidance TAVR can offer a feasible and safer strategy for TAVR.
Interventions
None listed
Sponsors
Pan Xiangbin
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. symptomatic severe AS determined by echocardiography and Doppler that requiring aortic valve replacement, which is defined as: mean gradient ≥40 mmHg, peak aortic velocity ≥4 m/s, and aortic valve area (AVA) ≤1 cm2 (or an indexed AVA ≤0.6 cm2/m2); 2. a history of malignancy or a high familial risk of cancer, with refusal to undergo contrast- or radiation-guided procedures; 3. chronic kidney disease and refuse to receive contrast agents or radiation exposure.
Exclusion criteria
Required hybrid procedures or concomitant interventions on other cardiac malformations; Deemed inoperable due to extremely high surgical risk or severe comorbidities; Had untreated clinically significant coronary vascular disease amenable to revascularization; Previously undergone aortic valve replacement.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Valve Academic Research Consortium-3 (VARC-3) | 30-day after surgery | VARC3 include but not limited to Mortality (all-cause and cardiovascular) Stroke and transient ischemic attack (TIA) Acute kidney injury Conduction disturbances and permanent pacemaker implantation Bleeding (updated using BARC criteria) Myocardial infarction Vascular access complications Endocarditis |
Countries
China
Contacts
Primary ContactXiangbin Pan, MD
Backup ContactFengwen Zhang, MD
Outcome results
None listed