Medication-Related Osteonecrosis of Jaw
Conditions
Brief summary
The aim of this study is assessing the effectiveness of the Er:YAG laser in relation to the use of conventional surgery in the treatment of drug-induced osteonecrosis of the jaws (MRONJ). The study compares two main treatments for advanced cases of MRONJ or cases that do not show improvement despite conservative or non-surgical treatment.
Interventions
PROCEDUREirradiation with Er:YAG laser
An Er:YAG laser (LightTouch, LightInstruments, Yokneam, Israel) was used with the following parameters: 400mJ (millijoules), 6W (Watt), 15Hz (Hertz), 5/8 water cooling, laser tip with a diameter of 800 microns. Tissue debridement continued until hard, healthy, lively bleeding bone was exposed, indicative of normal bone.
PROCEDURETissue preparation
Rose-shaped rotary drills (8 mm diameter) were used with water cooling at a speed not exceeding 40.000 rpm. Tissue preparation limits were consistent with those used for the Er:YAG laser group.
Sponsors
Wroclaw Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* confirmed diagnosis of MRONJ
Exclusion criteria
* head and neck radiotherapy * cases requiring hospital admission due to poor general condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complications | Up to 6 months | Occurrence or absence of complications |
Other
| Measure | Time frame | Description |
|---|---|---|
| Severity of Osteonecrosis | 3 and 6 months after treatment. | Incidence of grade II/III necrosis or no severe necrosis |
Countries
Poland
Outcome results
None listed