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Investigation of Inspiratory Muscle Training Applied at Different Intensities on Intercostal Muscle Oxygenation

Investigation of the Acute Effect of Inspiratory Muscle Training Applied at Different Intensities on Intercostal Muscle Oxygenation

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07029074
Enrollment
30
Registered
2025-06-19
Start date
2025-07-24
Completion date
2026-06-15
Last updated
2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

muscle oxygenation, inspiratory muscle training, intercostal muscle

Brief summary

In this study, it was aimed to investigate the acute effect of inspiratory muscle training of different intensities on intercostal muscle oxygenation in healthy individuals.

Detailed description

The functional activity of the respiratory system must be regular and efficient in order to meet the oxygen needs of tissues and organs. The mechanical function of the respiratory system is significantly related to the working capacity of the respiratory muscles. The diaphragm is the primary muscle that provides respiratory functions among the respiratory muscles.The external intercostal muscles help with the inspiration, while the internal intercostal muscles help with the expiration. The basis of inspiratory muscle training is to reduce dyspnea, increase inspiratory muscle function and exercise tolerance. Inspiratory muscle training provides an increase in muscle strength by increasing inspiratory muscle strength, reducing metaboreflex activity and increasing blood flow to the muscles. Training is thought to minimize the effects of activation of inspiratory muscle metaboreflex in both healthy individuals and patients with heart failure. In chronic respiratory patients, forced inspiration effort reduces capillary perfusion of the respiratory muscles, thus increasing the oxygen demand of the muscle. Muscle oxygen saturation shows the oxygen uptake and oxygen consumption of the muscle. It aims to investigate the mechanisms involved in the metaboreflex response to respiratory fatigue in inspiratory muscle training, which severity will acutely reduce it more.

Interventions

DEVICESham inspiratory muscle training (MIP 0%)

POWERbreathe Wellness (POWERbreathe International Ltd.., England, UK) device will be used for inspiratory muscle training.

DEVICEMIP 30% inspiratory muscle training

POWERbreathe Wellness (POWERbreathe International Ltd.., England, UK) device will be used for inspiratory muscle training.

OTHERMIP 70% inspiratory muscle training

POWERbreathe Wellness (POWERbreathe International Ltd.., England, UK) device will be used for inspiratory muscle training.

Sponsors

Kirsehir Ahi Evran Universitesi
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Intervention model description

This study was designed as a single-blind randomized, placebo-controlled, crossover study.

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No

Inclusion criteria

* Physically active (doing moderate intensity physical activity for at least 3 days a week for 150 minutes / week) * Volunteer to participate in the study

Exclusion criteria

* Healthy individuals with any diagnosed chronic or systemic disease, * Smoke 10 packs x years or more, * Pneumonia or any acute infection, * Psychiatric disorder will excluded in the study.

Design outcomes

Primary

MeasureTime frameDescription
Evaluation of intercostal muscle oxygenationSecond, Third and Fourth dayBefore the inspiratory muscle training sessions, the muscle oxygen saturation (SmO2) of the intercostal muscles in recovery during and after the training session will be measured using a Moxy® monitor (Moxy, Fortiori Design LLC, Minnesota, USA).
Evaluation of intercostal muscle total hemoglobin levelSecond, Third and Fourth dayBefore the inspiratory muscle training sessions, total hemoglobin level (THb) of the intercostal muscles in recovery during and after the training session will be measured using a Moxy® monitor (Moxy, Fortiori Design LLC, Minnesota, USA).

Secondary

MeasureTime frameDescription
Evaluation of respiratory muscle strengthFirst dayAn electronic mouth pressure device will be used to evaluate respiratory muscle strength. Patients will have maximal inspiratory pressure and maximal expiratory pressure measured with a mouth pressure measuring device.
Evaluation of respiratory muscle enduranceFirst dayThe incremental threshold loading test will be used to evaluate respiratory muscle endurance. The PowerBreathe Wellness® (HaB International Ltd. Southam, UK) will be used in the incremental threshold loading test.
Evaluation of physical activity levelFirst dayThe physical activity level of individuals will be evaluated using the short form of the International Physical Activity Questionnaire. A score is obtained by multiplying the metabolic equivalent (MET) value by days and minutes. When calculating the walking score, the walking time will be multiplied by 3.3 METs; when calculating the moderate intensity activity score, it will be multiplied by 4 METs; when calculating the vigorous activity score, it will be multiplied by 8 METs. Physical activity levels will be classified as physically inactive (3000 MET-min/week).

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 21, 2026