Luteal Phase Insufficiency
Conditions
Brief summary
This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels. The goal is to understand whether hCG affects the timing of the luteal phase and embryo implantation.
Interventions
DRUGhCG
Subcutaneous injection of 250 µg of recombinant hCG (Ovitrelle®)
Sponsors
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* At least 1 follicle of 14 mm or more * Endometrium of 6 mm or more * Plasma luteinizing hormone (LH) less than 2 times basal level (measured at the beginning of the cycle between D1 and D4) and progesteronemia less than 1.5 ng/mL * For whom ovulation induction with recombinant hCG (Ovitrelle) is then proposed (standard care).
Exclusion criteria
* Patient whose venous capital contraindicates repeated blood sampling over a short period of time over a short period. * Patient treated with exogenous natural progesterone (vaginal or injectable) which may interfere or synthetic progesterone, which may interfere with endogenous progesterone secretion. * Patient who has not given written consent to participate in the study. * Patient not fluent in French. * Patient under guardianship, curators or without social security coverage. * Patient participating in another study with an ongoing exclusion period or other interventional research with no ongoing exclusion period involves the use of a drug or procedure capable of altering progesterone levels .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Progesterone Level on Day 3 After hCG Trigger | 3 Days After hCG Injection |
Countries
France
Contacts
CONTACTNoémie RANISAVLJEVIC, Senior Lecturer - Hospital Pra
CONTACTAnne CADENE, Project manager
PRINCIPAL_INVESTIGATORNoémie RANISAVLJEVIC, Investigator Coordinator
CHU de Montpellier
Outcome results
None listed