Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute Diverticulitis

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07027007

Acronym

DIVENDO

Enrollment

Registered

2025-06-18

Start date

2025-09-30

Completion date

2027-09-30

Last updated

2025-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diverticulitis

Keywords

endocan, acute diverticolitis, diverticulitis classification

Brief summary

Quantify the level of endocan in blood samples collected from patients with acute diverticulitis in the emergency department. Determine if endocan levels are correlated with the severity of diverticulitis according to the WSES classification. Assess whether patients requiring emergency surgical intervention have higher endocan values compared to others.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients who have signed informed consent * Patients who are affected by acute diverticulitis after clinical evaluation and imaging (i.e. u.s. or CeCT)

Exclusion criteria

* Immunosuppressed patients * Patients suffering chronic inflammatory diseases * Patients with concomitant malignancy, cardiac, renal and haepatic failure * History of major vascular surgery (aneurysmectomy) * Pregnant women * Patients participating in other studies that may interfere with the outcome of the intervention.

Design outcomes

Primary

Measure	Time frame	Description
Endocan serum level at admission	The serum of the patients enrolled inthe study will be collected within two hours from emergency room registation and tested for ENDOCAN	To evaluate the correlation between blood concentration of endocan and severity of diverticulitis

Secondary

Measure	Time frame	Description
Predictive value of endocan in determining which patients need emergency surgery	Patients will undergo diverticulitis evaluations (per WSES criteria) within 3 hours of Emergency room admission and study enrollment	Concentration of endocan in grade 3-4 WSES compared to grade1-2
Prognostic value of endocan in determining the risk of recurrent diveritculitis	From discharge after definitive tretament till 12 months follow-up	Concentration of endocan in patient who develop a recurrence after 1 year follow-up

Countries

Italy

Outcome results