Gastric-type Endocervical Adenocarcinoma
Conditions
Brief summary
This retrospective cohort study analyzes the effect of surgical resection on survival outcomes in patients with gastric-type endocervical adenocarcinoma (GAS), using data from the SEER database (2000-2021). Propensity score matching and multivariable Cox regression were used to compare overall survival (OS) and tumor-specific survival (TSS) between patients who underwent surgery and those who did not. The study aims to determine whether primary tumor resection is associated with improved survival across tumor sizes and stages.
Detailed description
The study utilized de-identified data from the SEER program encompassing women aged ≥18 with histologically confirmed gastric-type endocervical adenocarcinoma between 2000 and 2021. The primary endpoints were overall survival and tumor-specific survival. Statistical analyses included multivariable Cox regression, propensity score matching (2:1), and inverse probability of treatment weighting (IPTW). Subgroup analyses were performed based on FIGO stage and tumor size (\>4 cm). A total of 308 eligible cases were included. No patient interaction or clinical intervention occurred.
Interventions
None listed
Sponsors
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Histologically confirmed gastric-type endocervical adenocarcinoma Cervix as the first primary site Diagnosis between 2000 and 2021
Exclusion criteria
Incomplete survival or treatment data Diagnosis not confirmed microscopically
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Outcome | Time from diagnosis to death from any cause Up to 22 years (2000-2022) | Overall Survival (OS) |
Outcome results
None listed