Diagnosis, Pulmonary Embolism (Diagnosis)
Conditions
Brief summary
A retrospective study to assess the utility of hematological marker (monocyte to large platelet ratio) to diagnose patients with pulmonary embolism
Detailed description
The investigators conducted a retrospective review of emergency department records of patients who presented with signs and symptoms suggestive of pulmonary embolism (PE) and underwent CT pulmonary angiography (CTPA) for diagnosis. Hematological laboratory findings obtained prior to any treatment were collected and compared between two groups based on CTPA results: those with confirmed PE (CT positive) and those without PE (CT negative).
Interventions
DIAGNOSTIC_TESTMonocyte to Large Platelet Ratio (MLPR)
Admission laboratory values were used to calculate the Monocyte-to-Large Platelet Ratio (MLPR) by dividing the absolute monocyte count by the large platelet count. These values were obtained from blood samples collected before any treatment was administered.
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Only patients with the results of full blood count and white blood cell differentiation, measured before the treatment of suspected PE. * Patients underwent CT pulmonary angiography to confirm or exclude pulmonary embolism diagnosis.
Exclusion criteria
* Patient with history of any myeloproliferative disorder, myelofibrosis, Glanzmann thrombasthenia, May-Hegglin anomaly, Bernard-Soulier syndrome, suspicion of disseminated intravascular coagulation. * Patient receiving any anticoagulant drug at a therapeutic dose. * Patient with blood transfusion in the last 2 months. * Patients with acute coronary syndrome, pulmonary edema. * Patient on immunosuppressive drugs , Oral contraceptive pills . * Patients with severe renal or hepatic disease. * Patients with Stroke. * Patients with malignancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Monocyte-to-Large Platelet Ratio (MLPR) | At emergency department admission (baseline lab measurement) before any treatment. | A ratio between monocyte absolute count and the large platelets count (MLPR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by area under the curve (AUC) , sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mean platelet volume (MPV) | At emergency department admission (baseline lab measurement) before any treatment. | MPV values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV. |
| Neutrophil to Lymphocyte Ratio (NLR) | At emergency department admission (baseline lab measurement) before any treatment. | The ratio between absolute neutrophil and absolute lymphocytes count (NLR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV. |
| D-Dimer Levels | At emergency department admission (baseline lab measurement) before any treatment. | D-Dimer concentration values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV. |
| Platelet Distribution Width (PDW) | At emergency department admission (baseline lab measurement) before any treatment. | PDW values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV. |
| Platelet To Lymphocyte Ratio (PLR) | At emergency department admission (baseline lab measurement) before any treatment. | The ratio between total platelets count and absolute lymphocytes count (PLR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by AUC, sensitivity, specificity, PPV, and NPV. |
Countries
Egypt
Contacts
STUDY_CHAIRReem H Elkabarity, Professor
Ain Shams University
STUDY_DIRECTORHadil M Abdelhamid, Professor
Ain Shams University
STUDY_DIRECTORAzza Lotfy, Professor
Ain Shams University
PRINCIPAL_INVESTIGATORMohamed k Awad, Lecturer
Ain Shams University
Outcome results
None listed