Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension

The Novel Use of Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension in Patients With Surgical Sepsis, a Double Blind Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07022730

Enrollment

Registered

2025-06-15

Start date

2025-06-22

Completion date

2025-09-17

Last updated

2025-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Induction Hypotension, Sepsis

Keywords

Hypotension, noradrenaline, sepsis

Brief summary

researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension

Detailed description

If post-induction hypotension is not addressed promptly, it can lead to severe complications such as reduced blood flow, acute kidney damage, and myocardial ischemia. As a result, early detection and proactive intervention are crucial. Researchers of the current study decided to investigate impact of noradrenaline administered as a prophylaxis on post induction hypotension

Interventions

DRUGNoradrenaline 0.2 mcg/kg/min at 5 minutes before induction

noradrenaline will be given at a rate of 0.2 mcg/kg/min that will start 5 minutes before induction

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Adult patients with sepsis undergoing source control surgery.

Exclusion criteria

* Patient refusal * Patient with cardiac pathology ( ischemic heart disease or heart failure) * Preoperative hemodynamic instability (defined as MAP \< 65 mmHg) * Rapid sequence induction

Design outcomes

Primary

Measure	Time frame	Description
Incidence of post induction hypotension in both groups	Within the first 10 minutes of induction.	Hypotension will be considered if MAP\< 65 mmHg

Secondary

Measure	Time frame	Description
Incidence of acute kidney injury	7 days post operative	defined as the highest postoperative value \> 1.5-fold or 0.3 mg/dL greater than the preoperative value
Incidence of myocardial infarction	7 days postoperative	defined as a peak troponin T value exceeding 15 times the normal upper limit, along with new pathological Q waves, ST elevation or depression, and hyperacute T wave on ECG and symptoms suggestive of myocardial infarction
Incidence of stroke	7 days postoperative	clinical or image finding of stroke

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026