Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07022028

Acronym

GUIMAUVE

Enrollment

800

Registered

2025-06-15

Start date

2024-02-27

Completion date

2024-11-06

Last updated

2025-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Guillain-Barre Syndrome, Myasthenia Gravis

Keywords

Myasthenia Gravis, Guillain-Barre syndrome, Ventilator Weaning, Airway Extubation, Intensive Care Unit

Brief summary

Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols. To date, no study has compared weaning modalities from mechanical ventilation in patients with these two diseases. Our objective was to assess and compare for ventilator weaning modalities between patients mechanically ventilated for Guillain-Barré syndrome or for myasthenia gravis in a large-scale multicenter study.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

All patients mechanically ventilated for at least 48 hours for Guillain-Barré syndrome or myasthenia gravis -

Exclusion criteria

Patients mechanically ventilated less than 48h or intubated for another reason than the neuromuscular disease. \-

Design outcomes

Primary

Measure	Time frame	Description
The proportion of patients with prolonged weaning	7 days after the initial separation attempt from the ventilator	Prolonged weaning defined as still being under mechanical ventilation at least 7 days after the initial separation attempt from the ventilator

Countries

France

Outcome results