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Prince of Wales Hospital Structural Heart Registry

Prince of Wales Hospital Structural Heart Registry

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07020286
Enrollment
1000
Registered
2025-06-13
Start date
2024-08-01
Completion date
2030-03-31
Last updated
2026-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Structural Heart Abnormality

Brief summary

Structural heart disease refers to a group of cardiac defects other than coronary artery disease. Structural heart intervention is a rapidly growing field in cardiology. In the past decade, there has been paradigm shift in the management of structural heart disease from conventional open-heart surgery to transcatheter interventions. With increasing evidence supporting structural heart interventions including transcatheter aortic valve implantation or transcatheter edge to edge repair, there has important updates in recent guidelines in treating structural heart disease. Besides, new device innovations bloomed over the past few years and had expanded the possible treatment options for high surgical risk patients. Some breakthrough devices had been approved recently by the US Food and Drug Administration and some other devices are occasionally used on compassionate ground. However, there has been lack of data in structural heart interventions in Asia Pacific regions outside Japan \[8\]. In this study, we would like to analyze the epidemiological trends, patient characteristics, procedural outcomes and clinical outcomes of structural heart interventions, and compare them with historical cohorts, matched cohort receiving medical therapy and matched cohort receiving open heart surgeries.

Interventions

PROCEDUREStructural heart interventions

The study allows us to understand the trend of transcatheter interventions in structural heart disease, clinical outcomes and allows the comparison of the outcomes of structural heart interventions to medical therapy and surgery at PWH, and to HA hospitals.

Sponsors

Prince of Wales Hospital, Shatin, Hong Kong
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years

Inclusion criteria

* All patients undergoing structural heart interventions at the Prince of Wales Hospital

Exclusion criteria

* Patients that are not able to consent.

Design outcomes

Primary

MeasureTime frameDescription
Procedural success ratePost-procedure until 1 year post OPProcedural success rate
Procedural safety endpointsPost-procedure until 1 year post OPRate of vascular complication in enrolled subjects , ,

Secondary

MeasureTime frameDescription
Clinical outcome3 monthsNTproBNP at 3 months
Echocardiogram outcome3 monthsperi-device leak at post-OP 3 months compared with baseline

Countries

Hong Kong

Contacts

CONTACTKent So, PI
kentso@cuhk.edu.hk85235051518
STUDY_DIRECTORDaniel Xu, Research Nurse

Chinese University of Hong Kong

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 17, 2026