Cardiac Arrest, Coma, Critical Illness, Hypoxic-Ischemic Encephalopathy, Post-Resuscitation Syndrome
Conditions
Keywords
Cardiac Arrest, ROSC, In-Hospital Mortality, ICU, Post-Resuscitation Care, Neurological Outcome
Brief summary
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest. Eligible patients admitted to the intensive care unit between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval. Clinical, biochemical, and resuscitation-related parameters recorded within the first 24 hours of ICU admission were analyzed. The primary objective was to determine factors independently associated with short-term mortality. Six-month mortality was additionally assessed using hospital records and the national death registry. The findings are expected to improve risk stratification and clinical decision-making in post-cardiac arrest care.
Detailed description
This retrospective observational cohort study was conducted in the intensive care unit (ICU) of Gazi Yaşargil Training and Research Hospital, Turkey. Adult patients (≥18 years) who achieved return of spontaneous circulation (ROSC) after cardiac arrest and were admitted to the ICU between January 1, 2024 and May 31, 2025 were identified retrospectively from electronic medical records following institutional ethics approval. Baseline demographic, clinical, laboratory, and resuscitation-related variables recorded within the first 24 hours of ICU admission were extracted from hospital records. These variables included arrest characteristics, time to ROSC, initial rhythm, hemodynamic parameters, neurological status, laboratory biomarkers, and therapeutic interventions routinely performed in ICU practice. The primary outcome was 30-day all-cause mortality. Secondary outcomes included 24-hour, 7-day, and 6-month mortality, neurological outcome at hospital discharge, and ICU length of stay. Six-month mortality status was confirmed using hospital records and the national death registry. A total of 168 eligible patients were identified during the study period. Multivariate logistic regression analysis was performed to identify independent predictors of mortality. No interventions beyond routine clinical care were conducted.
Interventions
None listed
Sponsors
Ahmet Düzgün
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Achieved return of spontaneous circulation (ROSC) after cardiac arrest * Admitted to the intensive care unit (ICU) * Informed consent obtained from patient or legal representative (if applicable)
Exclusion criteria
* Age \< 18 years * Known pregnancy * Brain death at the time of ICU admission * Patients with missing key clinical or laboratory data * Declined participation or legal refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 30-Day Mortality | 30 days after ICU admission | All-cause mortality within 30 days of ICU admission following ROSC. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| In-Hospital Mortality | From ICU admission to hospital discharge (up to 60 days) | All-cause mortality recorded during the index hospital stay following return of spontaneous circulation (ROSC). |
| 6-Month Mortality | 6 months after ICU admission | All-cause mortality assessed at 6 months following the initial cardiac arrest event. Mortality status is confirmed through hospital records and national death registry. |
Countries
Turkey (Türkiye)
Participant flow
Recruitment details
A total of 168 adult patients admitted to the intensive care unit after return of spontaneous circulation following cardiac arrest were included in this retrospective cohort study.
Pre-assignment details
Eligible patients were identified retrospectively from institutional records and included in the analysis.
Baseline characteristics
| Characteristic | — |
|---|---|
| Age, Continuous | 69.5 years STANDARD_DEVIATION 16.2 |
| APACHE II score | 24.3 score STANDARD_DEVIATION 6.3 |
| Charlson Comorbidity Index | 5.5 score STANDARD_DEVIATION 2.3 |
| SAPS 3 score | 83.6 score STANDARD_DEVIATION 16.4 |
| Sex: Female, Male Female | 77 Participants |
| Sex: Female, Male Male | 91 Participants |
| SOFA score | 8.6 score STANDARD_DEVIATION 2.5 |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 130 / 168 |
| other Total, other adverse events | 0 / 168 |
| serious Total, serious adverse events | 0 / 168 |
Outcome results
None listed